Names & Taxonomy
- Uniprot ID:
- Q9UHY7
- Entry Name:
- ENOPH_HUMAN
- Status:
- reviewed
- Protein Names:
- Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase) (MASA homolog)
- Gene Names:
- ENOPH1 MASA MSTP145
- Gene Names Orf:
- MSTP145
- Gene Names Primary:
- ENOPH1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 261
- Sequence:
- MVVLSVPAEVTVILLDIEGTTTPIAFVKDILFPYIEENVKEYLQTHWEEEECQQDVSLLRKQAEEDAHLDGAVPIPAASGNGVDDLQQMIQAVVDNVCWQMSLDRKTTALKQLQGHMWRAAFTAGRMKAEFFADVVPAVRKWREAGMKVYIYSSGSVEAQKLLFGHSTEGDILELVDGHFDTKIGHKVESESYRKIADSIGCSTNNILFLTDVTREASAAEEADVHVAVVVRPGNAGLTDDEKTYYSLITSFSELYLPSST
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
- Pathway:
- Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.
- Catalytic Activity:
- 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; ; Note=Binds 1 Mg(2+) ion per subunit.;
- Gene Ontology Go:
- cytosol
extracellular exosome
nucleus
acireductone synthase activity
magnesium ion binding
cellular nitrogen compound metabolic process
dephosphorylation
L-methionine biosynthetic process from methylthioadenosine
polyamine metabolic process
small molecule metabolic process
sulfur amino acid metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
dephosphorylation
L-methionine biosynthetic process from methylthioadenosine
polyamine metabolic process
small molecule metabolic process
sulfur amino acid metabolic process - Gene Ontology Molecular Function:
- acireductone synthase activity
magnesium ion binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
nucleus - Keywords:
- 3D-structure
Alternative splicing
Amino-acid biosynthesis
Complete proteome
Cytoplasm
Hydrolase
Magnesium
Metal-binding
Methionine biosynthesis
Nucleus
Reference proteome