Names & Taxonomy
- Uniprot ID:
- Q9UHI7
- Entry Name:
- S23A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (hSVCT1) (Yolk sac permease-like molecule 3)
- Gene Names:
- SLC23A1 SVCT1 YSPL3
- Gene Names Primary:
- SLC23A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 598
- Sequence:
- MRAQEDLEGRTQHETTRDPSTPLPTEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGHDQHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKAILALERWKCPPEEEIYGNWSLPLNTSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGALLNYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIILFSQYLRNLTFLLPVYRWGKGLTLLRIQIFKMFPIMLAIMTVWLLCYVLTLTDVLPTDPKAYGFQARTDARGDIMAIAPWIRIPYPCQWGLPTVTAAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAAIMLVLGTIGKFTALFSSLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLESNPGAINTGILEVDQILIVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSDMSSSLKSYDFPIGMGIVKRITFLKYIPICPVFKGFSSSSKDQIAIPEDTPENTETASVCTKV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
- Intramembrane:
- INTRAMEM 230 243 Helical.
Function
- Function:
- Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
- Cross Reference Drug Bank:
- DB00126
- Gene Ontology Go:
- apical plasma membrane
basal plasma membrane
cytoplasm
extracellular exosome
integral component of plasma membrane
intracellular organelle
membrane
plasma membrane
dehydroascorbic acid transporter activity
L-ascorbate:sodium symporter activity
L-ascorbic acid transporter activity
nucleobase transmembrane transporter activity
sodium ion transmembrane transporter activity
sodium-dependent L-ascorbate transmembrane transporter activity
brain development
carboxylic acid transmembrane transport
dehydroascorbic acid transport
L-ascorbic acid metabolic process
L-ascorbic acid transport
lung development
nucleobase transport
nucleobase-containing compound metabolic process
response to toxic substance
small molecule metabolic process
sodium ion transmembrane transport
sodium ion transport
transepithelial L-ascorbic acid transport
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- brain development
carboxylic acid transmembrane transport
dehydroascorbic acid transport
L-ascorbic acid metabolic process
L-ascorbic acid transport
lung development
nucleobase-containing compound metabolic process
nucleobase transport
response to toxic substance
small molecule metabolic process
sodium ion transmembrane transport
sodium ion transport
transepithelial L-ascorbic acid transport
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- dehydroascorbic acid transporter activity
L-ascorbate:sodium symporter activity
L-ascorbic acid transporter activity
nucleobase transmembrane transporter activity
sodium-dependent L-ascorbate transmembrane transporter activity
sodium ion transmembrane transporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
basal plasma membrane
cytoplasm
extracellular exosome
integral component of plasma membrane
intracellular organelle
membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q6UY14-3; O43865; Q15323; P60370; P60409; P60410; P60411; Q9BYR5; Q5JR59; P16333; Q7Z3S9