Names & Taxonomy
- Uniprot ID:
- Q9UHI5
- Entry Name:
- LAT2_HUMAN
- Status:
- reviewed
- Protein Names:
- Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8)
- Gene Names:
- SLC7A8 LAT2
- Gene Names Primary:
- SLC7A8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 535
- Sequence:
- MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEVERGSGTEEANEDMEEQQQPMYQPTPTKDKDVAGQPQP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Basolateral cell membrane; Multi-pass membrane protein. Note=Localized to the cytoplasm when expressed alone but when coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi.
Function
- Function:
- Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=221 uM for L-leucine
- Cross Reference Drug Bank:
- DB00160 DB00130 DB00120 DB01235
- Gene Ontology Go:
- basolateral plasma membrane
cytoplasm
extracellular exosome
integral component of plasma membrane
plasma membrane
amino acid transmembrane transporter activity
antiporter activity
L-amino acid transmembrane transporter activity
neutral amino acid transmembrane transporter activity
organic cation transmembrane transporter activity
peptide antigen binding
toxin transporter activity
amino acid transport
blood coagulation
cellular amino acid metabolic process
ion transport
leukocyte migration
metal ion homeostasis
neutral amino acid transport
organic cation transport
response to toxic substance
toxin transport
transmembrane transport
transport - Gene Ontology Biological Process:
- amino acid transport
blood coagulation
cellular amino acid metabolic process
ion transport
leukocyte migration
metal ion homeostasis
neutral amino acid transport
organic cation transport
response to toxic substance
toxin transport
transmembrane transport
transport - Gene Ontology Molecular Function:
- amino acid transmembrane transporter activity
antiporter activity
L-amino acid transmembrane transporter activity
neutral amino acid transmembrane transporter activity
organic cation transmembrane transporter activity
peptide antigen binding
toxin transporter activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
cytoplasm
extracellular exosome
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Amino-acid transport
Cell membrane
Complete proteome
Cytoplasm
Disulfide bond
Membrane
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix
Transport