Names & Taxonomy
- Uniprot ID:
- Q9UGM6
- Entry Name:
- SYWM_HUMAN
- Status:
- reviewed
- Protein Names:
- Tryptophan--tRNA ligase, mitochondrial (EC 6.1.1.2) ((Mt)TrpRS) (Tryptophanyl-tRNA synthetase) (TrpRS)
- Gene Names:
- WARS2
- Gene Names Primary:
- WARS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 360
- Sequence:
- MALHSMRKARERWSFIRALHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Catalytic Activity:
- ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).
- Cross Reference Drug Bank:
- DB00150
- Gene Ontology Go:
- mitochondrial matrix
ATP binding
tryptophan-tRNA ligase activity
gene expression
tRNA aminoacylation for protein translation
tryptophanyl-tRNA aminoacylation
vasculogenesis - Gene Ontology Biological Process:
- gene expression
tRNA aminoacylation for protein translation
tryptophanyl-tRNA aminoacylation
vasculogenesis - Gene Ontology Molecular Function:
- ATP binding
tryptophan-tRNA ligase activity - Gene Ontology Cellular Component:
- mitochondrial matrix
- Keywords:
- ATP-binding
Alternative splicing
Aminoacyl-tRNA synthetase
Complete proteome
Ligase
Mitochondrion
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide