Names & Taxonomy
- Uniprot ID:
- Q9UG01
- Entry Name:
- IF172_HUMAN
- Status:
- reviewed
- Protein Names:
- Intraflagellar transport protein 172 homolog
- Gene Names:
- IFT172 KIAA1179
- Gene Names Primary:
- IFT172
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1749
- Sequence:
- MHLKHLRTLLSPQDGAAKVTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGRKSYMVKGMAFSPDSTKIAIGQTDNIIYVYKIGEDWGDKKVICNKFIQTSAVTCLQWPAEYIIVFGLAEGKVRLANTKTNKSSTIYGTESYVVSLTTNCSGKGILSGHADGTIVRYFFDDEGSGESQGKLVNHPCPPYALAWATNSIVAAGCDRKIVAYGKEGHMLQTFDYSRDPQEREFTTAVSSPGGQSVVLGSYDRLRVFNWIPRRSIWEEAKPKEITNLYTITALAWKRDGSRLCVGTLCGGVEQFDCCLRRSIYKNKFELTYVGPSQVIVKNLSSGTRVVLKSHYGYEVEEVKILGKERYLVAHTSETLLLGDLNTNRLSEIAWQGSGGNEKYFFENENVCMIFNAGELTLVEYGNNDTLGSVRTEFMNPHLISVRINERCQRGTEDNKKLAYLIDIKTIAIVDLIGGYNIGTVSHESRVDWLELNETGHKLLFRDRKLRLHLYDIESCSKTMILNFCSYMQWVPGSDVLVAQNRNSLCVWYNIEAPERVTMFTIRGDVIGLERGGGKTEVMVMEGVTTVAYTLDEGLIEFGTAIDDGNYIRATAFLETLEMTPETEAMWKTLSKLALEARQLHIAERCFSALGQVAKARFLHETNEIADQVSREYGGEGTDFYQVRARLAMLEKNYKLAEMIFLEQNAVEEAMGMYQELHRWDECIAVAEAKGHPALEKLRRSYYQWLMDTQQEERAGELQESQGDGLAAISLYLKAGLPAKAARLVLTREELLANTELVEHITAALIKGELYERAGDLFEKIHNPQKALECYRKGNAFMKAVELARLAFPVEVVKLEEAWGDHLVQQKQLDAAINHYIEARCSIKAIEAALGARQWKKAIYILDLQDRNTASKYYPLVAQHYASLQEYEIAEELYTKGDRTKDAIDMYTQAGRWEQAHKLAMKCMRPEDVSVLYITQAQEMEKQGKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLVGKHHPDLLSDTHLHLGKELEAEGRLQEAEYHYLEAQEWKATVNMYRASGLWEEAYRVARTQGGANAHKHVAYLWAKSLGGEAAVRLLNKLGLLEAAVDHAADNCSFEFAFELSRLALKHKTPEVHLKYAMFLEDEGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVGQARGALEEKDFQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPSQLEALQEEYEREATKKGARGVEGFVEQARHWEQAGEYSRAVDCYLKVRDSGNSGLAEKCWMKAAELSIKFLPPQRNMEVVLAVGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRVAKELDPRYEDYVDQHYKEFLKNQGKVDSLVGVDVIAALDLYVEQGQWDKCIETATKQNYKILHKYVALYATHLIREGSSAQALALYVQHGAPANPQNFNIYKRIFTDMVSSPGTNCAEAYHSWADLRDVLFNLCENLVKSSEANSPAHEEFKTMLLIAHYYATRSAAQSVKQLETVAARLSVSLLRHTQLLPVDKAFYEAGIAAKAVGWDNMAFIFLNRFLDLTDAIEEGTLDGLDHSDFQDTDIPFEVPLPAKQHVPEAEREEVRDWVLTVSMDQRLEQVLPRDERGAYEASLVAASTGVRALPCLITGYPILRNKIEFKRPGKAANKDNWNKFLMAIKTSHSPVCQDVLKFISQWCGGLPSTSFSFQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell projection, cilium
Function
- Function:
- Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity).
- Gene Ontology Go:
- axoneme
ciliary basal body
ciliary tip
cilium
extracellular vesicle
intraciliary transport particle B
primary cilium
sperm cytoplasmic droplet
sperm midpiece
sperm principal piece
bone development
brain development
cilium assembly
cytoplasmic microtubule organization
dorsal/ventral pattern formation
epidermis development
heart looping
hindgut development
left/right axis specification
limb development
negative regulation of epithelial cell proliferation
neural tube closure
Notch signaling pathway
organelle organization
palate development
positive regulation of smoothened signaling pathway
protein processing
smoothened signaling pathway
spinal cord motor neuron differentiation - Gene Ontology Biological Process:
- bone development
brain development
cilium assembly
cytoplasmic microtubule organization
dorsal/ventral pattern formation
epidermis development
heart looping
hindgut development
left/right axis specification
limb development
negative regulation of epithelial cell proliferation
neural tube closure
Notch signaling pathway
organelle organization
palate development
positive regulation of smoothened signaling pathway
protein processing
smoothened signaling pathway
spinal cord motor neuron differentiation - Gene Ontology Cellular Component:
- axoneme
ciliary basal body
ciliary tip
cilium
extracellular vesicle
intraciliary transport particle B
primary cilium
sperm cytoplasmic droplet
sperm midpiece
sperm principal piece - Keywords:
- Acetylation
Alternative splicing
Cell projection
Ciliopathy
Cilium
Complete proteome
Developmental protein
Disease mutation
Isopeptide bond
Polymorphism
Reference proteome
Repeat
Retinitis pigmentosa
TPR repeat
Ubl conjugation
WD repeat