Names & Taxonomy
- Uniprot ID:
- Q9UBY0
- Entry Name:
- SL9A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2)
- Gene Names:
- SLC9A2 NHE2
- Gene Names Primary:
- SLC9A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 812
- Sequence:
- MEPLGNWRSLRAPLPPMLLLLLLQVAGPVGALAETLLNAPRAMGTSSSPPSPASVVAPGTTLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFSKKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDSLTEGIPPKPPPRLVWRASEPGSRKARFGSEKP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
- Intramembrane:
- INTRAMEM 14 33 Name=A/M1.
Function
- Function:
- Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.
- Gene Ontology Go:
- integral component of membrane
plasma membrane
sodium:proton antiporter activity
ion transport
protein localization
regulation of pH
transmembrane transport - Gene Ontology Biological Process:
- ion transport
protein localization
regulation of pH
transmembrane transport - Gene Ontology Molecular Function:
- sodium:proton antiporter activity
- Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane - Keywords:
- Antiport
Complete proteome
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium transport
Transmembrane
Transmembrane helix
Transport