Names & Taxonomy
- Uniprot ID:
- Q9UBX1
- Entry Name:
- CATF_HUMAN
- Status:
- reviewed
- Protein Names:
- Cathepsin F (CATSF) (EC 3.4.22.41)
- Gene Names:
- CTSF
- Gene Names Primary:
- CTSF
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 484
- Sequence:
- MAPWLQLLSLLGLLPGAVAAPAQPRAASFQAWGPPSPELLAPTRFALEMFNRGRAAGTRAVLGLVRGRVRRAGQGSLYSLEATLEEPPCNDPMVCRLPVSKKTLLCSFQVLDELGRHVLLRKDCGPVDTKVPGAGEPKSAFTQGSAMISSLSQNHPDNRNETFSSVISLLNEDPLSQDLPVKMASIFKNFVITYNRTYESKEEARWRLSVFVNNMVRAQKIQALDRGTAQYGVTKFSDLTEEEFRTIYLNTLLRKEPGNKMKQAKSVGDLAPPEWDWRSKGAVTKVKDQGMCGSCWAFSVTGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACMGGLPSNAYSAIKNLGGLETEDDYSYQGHMQSCNFSAEKAKVYINDSVELSQNEQKLAAWLAKRGPISVAINAFGMQFYRHGISRPLRPLCSPWLIDHAVLLVGYGNRSDVPFWAIKNSWGTDWGEKGYYYLHRGSGACGVNTMASSAVVD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome.
Function
- Function:
- Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
- Catalytic Activity:
- The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (k(cat)/K(m)) comparable to that of cathepsin L.
- Active Site:
- ACT_SITE 295 295
- Gene Ontology Go:
- extracellular exosome
extracellular space
extracellular vesicle
lysosomal lumen
lysosome
cysteine-type endopeptidase activity
antigen processing and presentation of exogenous peptide antigen via MHC class II
proteolysis
proteolysis involved in cellular protein catabolic process - Gene Ontology Biological Process:
- antigen processing and presentation of exogenous peptide antigen via MHC class II
proteolysis
proteolysis involved in cellular protein catabolic process - Gene Ontology Molecular Function:
- cysteine-type endopeptidase activity
- Gene Ontology Cellular Component:
- extracellular exosome
extracellular space
extracellular vesicle
lysosomal lumen
lysosome - Keywords:
- 3D-structure
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Neurodegeneration
Neuronal ceroid lipofuscinosis
Polymorphism
Protease
Reference proteome
Signal
Thiol protease
Zymogen