Names & Taxonomy

Uniprot ID:
Q9UBX1
Entry Name:
CATF_HUMAN
Status:
reviewed
Protein Names:
Cathepsin F (CATSF) (EC 3.4.22.41)
Gene Names:
CTSF
Gene Names Primary:
CTSF
Organism:
Homo sapiens (Human)

Structure

Length:
484
Sequence:
MAPWLQLLSLLGLLPGAVAAPAQPRAASFQAWGPPSPELLAPTRFALEMFNRGRAAGTRAVLGLVRGRVRRAGQGSLYSLEATLEEPPCNDPMVCRLPVSKKTLLCSFQVLDELGRHVLLRKDCGPVDTKVPGAGEPKSAFTQGSAMISSLSQNHPDNRNETFSSVISLLNEDPLSQDLPVKMASIFKNFVITYNRTYESKEEARWRLSVFVNNMVRAQKIQALDRGTAQYGVTKFSDLTEEEFRTIYLNTLLRKEPGNKMKQAKSVGDLAPPEWDWRSKGAVTKVKDQGMCGSCWAFSVTGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACMGGLPSNAYSAIKNLGGLETEDDYSYQGHMQSCNFSAEKAKVYINDSVELSQNEQKLAAWLAKRGPISVAINAFGMQFYRHGISRPLRPLCSPWLIDHAVLLVGYGNRSDVPFWAIKNSWGTDWGEKGYYYLHRGSGACGVNTMASSAVVD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Lysosome.

Function

Function:
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
Catalytic Activity:
The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (k(cat)/K(m)) comparable to that of cathepsin L.
Active Site:
ACT_SITE 295 295
Gene Ontology Go:
extracellular exosome
extracellular space
extracellular vesicle
lysosomal lumen
lysosome
cysteine-type endopeptidase activity
antigen processing and presentation of exogenous peptide antigen via MHC class II
proteolysis
proteolysis involved in cellular protein catabolic process
Gene Ontology Biological Process:
antigen processing and presentation of exogenous peptide antigen via MHC class II
proteolysis
proteolysis involved in cellular protein catabolic process
Gene Ontology Molecular Function:
cysteine-type endopeptidase activity
Gene Ontology Cellular Component:
extracellular exosome
extracellular space
extracellular vesicle
lysosomal lumen
lysosome
Keywords:
3D-structure
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Neurodegeneration
Neuronal ceroid lipofuscinosis
Polymorphism
Protease
Reference proteome
Signal
Thiol protease
Zymogen

Publication

PubMed ID:
10318784 10198209 10661872 10362521 14702039 15489334 9822672 17974005 19159218 12225749 23297359