Names & Taxonomy
- Uniprot ID:
- Q9P2R7
- Entry Name:
- SUCB1_HUMAN
- Status:
- reviewed
- Protein Names:
- Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (Renal carcinoma antigen NY-REN-39) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)
- Gene Names:
- SUCLA2
- Gene Names Primary:
- SUCLA2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 463
- Sequence:
- MAASMFYGRLVAVATLRNHRPRTAQRAAAQVLGSSGLFNNHGLQVQQQQQRNLSLHEYMSMELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLKGGVKIVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGPVLIGSSHGGVNIEDVAAESPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESAAENMVKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDERDKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDAKALIADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- Catalyzes the ATP-dependent ligation of succinate and CoA to form succinyl-CoA.
- Pathway:
- Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
- Catalytic Activity:
- ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.
- Cross Reference Drug Bank:
- DB00139
- Gene Ontology Go:
- extracellular exosome
mitochondrial matrix
mitochondrion
myelin sheath
ATP binding
metal ion binding
succinate-CoA ligase (ADP-forming) activity
cellular metabolic process
small molecule metabolic process
succinate metabolic process
succinyl-CoA metabolic process
succinyl-CoA pathway
tricarboxylic acid cycle - Gene Ontology Biological Process:
- cellular metabolic process
small molecule metabolic process
succinate metabolic process
succinyl-CoA metabolic process
succinyl-CoA pathway
tricarboxylic acid cycle - Gene Ontology Molecular Function:
- ATP binding
metal ion binding
succinate-CoA ligase (ADP-forming) activity - Gene Ontology Cellular Component:
- extracellular exosome
mitochondrial matrix
mitochondrion
myelin sheath - Keywords:
- ATP-binding
Acetylation
Alternative splicing
Complete proteome
Disease mutation
Ligase
Mitochondrion
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide
Tricarboxylic acid cycle