Names & Taxonomy
- Uniprot ID:
- Q9P2L0
- Entry Name:
- WDR35_HUMAN
- Status:
- reviewed
- Protein Names:
- WD repeat-containing protein 35 (Intraflagellar transport protein 121 homolog)
- Gene Names:
- WDR35 IFT121 KIAA1336
- Gene Names Primary:
- WDR35
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1181
- Sequence:
- MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEIHIYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAVCFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHMGSVLAVAGFQKAAMQDKDVNIVQFYTPFGEHLGTLKVPGKEISALSWEGGGLKIALAVDSFIYFANIRPNYKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNNEKYVKYVKGLISITTCGDFCILATKADENHPQEENEMETFGATFVLVLCNSIGTPLDPKYIDIVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDTPSGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQKYSLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFVKRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIADEEAKKGSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCACASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTCVATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
- Function:
- Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis.
- Gene Ontology Go:
- axoneme
centrosome
ciliary basal body
ciliary tip
cilium
cytoplasm
intraciliary transport particle A
primary cilium
phosphatidylinositol binding
cilium assembly
intraciliary retrograde transport
organelle organization
protein localization to cilium - Gene Ontology Biological Process:
- cilium assembly
intraciliary retrograde transport
organelle organization
protein localization to cilium - Gene Ontology Molecular Function:
- phosphatidylinositol binding
- Gene Ontology Cellular Component:
- axoneme
centrosome
ciliary basal body
ciliary tip
cilium
cytoplasm
intraciliary transport particle A
primary cilium - Keywords:
- Alternative splicing
Cell projection
Ciliopathy
Cilium
Cilium biogenesis/degradation
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Ectodermal dysplasia
Polymorphism
Reference proteome
Repeat
WD repeat