Names & Taxonomy
- Uniprot ID:
- Q9P289
- Entry Name:
- STK26_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK)
- Gene Names:
- STK26 MASK MST4
- Gene Names Primary:
- STK26
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 416
- Sequence:
- MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Golgi apparatus.
Function
- Function:
- Mediator of cell growth. Modulates apoptosis.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Enzyme Regulation:
- ENZYME REGULATION: Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage.
- Active Site:
- ACT_SITE 144 144 Proton acceptor.
- Gene Ontology Go:
- apical plasma membrane
cell periphery
centrosome
cytoplasm
cytosol
extracellular exosome
Golgi apparatus
Golgi membrane
Golgi-associated vesicle
nucleus
perinuclear region of cytoplasm
ATP binding
identical protein binding
magnesium ion binding
protein homodimerization activity
protein kinase activity
protein serine/threonine kinase activity
Rac GTPase binding
actin cytoskeleton organization
activation of protein kinase activity
apoptotic process
cell migration
cellular component disassembly involved in execution phase of apoptosis
microvillus assembly
programmed cell death
protein autophosphorylation
protein phosphorylation
regulation of apoptotic process
regulation of hydrogen peroxide-induced cell death
regulation of MAPK cascade
regulation of mitotic cell cycle
response to hydrogen peroxide
Rho protein signal transduction
signal transduction by protein phosphorylation
stress-activated protein kinase signaling cascade - Gene Ontology Biological Process:
- actin cytoskeleton organization
activation of protein kinase activity
apoptotic process
cell migration
cellular component disassembly involved in execution phase of apoptosis
microvillus assembly
programmed cell death
protein autophosphorylation
protein phosphorylation
regulation of apoptotic process
regulation of hydrogen peroxide-induced cell death
regulation of MAPK cascade
regulation of mitotic cell cycle
response to hydrogen peroxide
Rho protein signal transduction
signal transduction by protein phosphorylation
stress-activated protein kinase signaling cascade - Gene Ontology Molecular Function:
- ATP binding
identical protein binding
magnesium ion binding
protein homodimerization activity
protein kinase activity
protein serine/threonine kinase activity
Rac GTPase binding - Gene Ontology Cellular Component:
- apical plasma membrane
cell periphery
centrosome
cytoplasm
cytosol
extracellular exosome
Golgi apparatus
Golgi-associated vesicle
Golgi membrane
nucleus
perinuclear region of cytoplasm - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Apoptosis
Complete proteome
Cytoplasm
Golgi apparatus
Kinase
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase - Interacts With:
- Itself; Q9Y376; Q9P2B4; Q5VSL9