Names & Taxonomy
- Uniprot ID:
- Q9P0Z9
- Entry Name:
- SOX_HUMAN
- Status:
- reviewed
- Protein Names:
- Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase)
- Gene Names:
- PIPOX LPIPOX PSO
- Gene Names Primary:
- PIPOX
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 390
- Sequence:
- MAAQKDLWDAIVIGAGIQGCFTAYHLAKHRKRILLLEQFFLPHSRGSSHGQSRIIRKAYLEDFYTRMMHECYQIWAQLEHEAGTQLHRQTGLLLLGMKENQELKTIQANLSRQRVEHQCLSSEELKQRFPNIRLPRGEVGLLDNSGGVIYAYKALRALQDAIRQLGGIVRDGEKVVEINPGLLVTVKTTSRSYQAKSLVITAGPWTNQLLRPLGIEMPLQTLRINVCYWREMVPGSYGVSQAFPCFLWLGLCPHHIYGLPTGEYPGLMKVSYHHGNHADPEERDCPTARTDIGDVQILSSFVRDHLPDLKPEPAVIESCMYTNTPDEQFILDRHPKYDNIVIGAGFSGHGFKLAPVVGKILYELSMKLTPSYDLAPFRISRFPSLGKAHL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Peroxisome.
Function
- Function:
- Metabolizes sarcosine, L-pipecolic acid and L-proline.
- Catalytic Activity:
- Sarcosine + H(2)O + O(2) = glycine + formaldehyde + H(2)O(2).; L-pipecolate + O(2) = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2).
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; ; Note=Binds 1 FAD per subunit.;
- Cross Reference Drug Bank:
- DB00145
- Gene Ontology Go:
- peroxisomal matrix
peroxisome
L-pipecolate oxidase activity
receptor binding
sarcosine oxidase activity
cellular nitrogen compound metabolic process
L-lysine catabolic process to acetyl-CoA via L-pipecolate
lysine catabolic process
oxidation-reduction process
small molecule metabolic process
tetrahydrofolate metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
L-lysine catabolic process to acetyl-CoA via L-pipecolate
lysine catabolic process
oxidation-reduction process
small molecule metabolic process
tetrahydrofolate metabolic process - Gene Ontology Molecular Function:
- L-pipecolate oxidase activity
receptor binding
sarcosine oxidase activity - Gene Ontology Cellular Component:
- peroxisomal matrix
peroxisome - Keywords:
- Acetylation
Complete proteome
FAD
Flavoprotein
Oxidoreductase
Peroxisome
Reference proteome - Interacts With:
- Q9NUX5