Names & Taxonomy
- Uniprot ID:
- Q9NYQ3
- Entry Name:
- HAOX2_HUMAN
- Status:
- reviewed
- Protein Names:
- Hydroxyacid oxidase 2 (HAOX2) (EC 1.1.3.15) ((S)-2-hydroxy-acid oxidase, peroxisomal) (Cell growth-inhibiting gene 16 protein) (Long chain alpha-hydroxy acid oxidase) (Long-chain L-2-hydroxy acid oxidase)
- Gene Names:
- HAO2 HAOX2 GIG16
- Gene Names Orf:
- GIG16
- Gene Names Primary:
- HAO2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 351
- Sequence:
- MSLVCLTDFQAHAREQLSKSTRDFIEGGADDSITRDDNIAAFKRIRLRPRYLRDVSEVDTRTTIQGEEISAPICIAPTGFHCLVWPDGEMSTARAAQAAGICYITSTFASCSLEDIVIAAPEGLRWFQLYVHPDLQLNKQLIQRVESLGFKALVITLDTPVCGNRRHDIRNQLRRNLTLTDLQSPKKGNAIPYFQMTPISTSLCWNDLSWFQSITRLPIILKGILTKEDAELAVKHNVQGIIVSNHGGRQLDEVLASIDALTEVVAAVKGKIEVYLDGGVRTGNDVLKALALGAKCIFLGRPILWGLACKGEHGVKEVLNILTNEFHTSMALTGCRSVAEINRNLVQFSRL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Peroxisome.
Function
- Function:
- Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.
- Catalytic Activity:
- (S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2).
- Cofactor:
- COFACTOR: Name=FMN; Xref=ChEBI:CHEBI:58210;
- Active Site:
- ACT_SITE 246 246 Proton acceptor.
- Gene Ontology Go:
- extracellular exosome
mitochondrion
peroxisomal matrix
peroxisome
(S)-2-hydroxy-acid oxidase activity
FMN binding
long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
medium-chain-(S)-2-hydroxy-acid oxidase activity
receptor binding
very-long-chain-(S)-2-hydroxy-acid oxidase activity
cellular lipid metabolic process
fatty acid oxidation
small molecule metabolic process - Gene Ontology Biological Process:
- cellular lipid metabolic process
fatty acid oxidation
small molecule metabolic process - Gene Ontology Molecular Function:
- (S)-2-hydroxy-acid oxidase activity
FMN binding
long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
medium-chain-(S)-2-hydroxy-acid oxidase activity
receptor binding
very-long-chain-(S)-2-hydroxy-acid oxidase activity - Gene Ontology Cellular Component:
- extracellular exosome
mitochondrion
peroxisomal matrix
peroxisome - Keywords:
- Alternative splicing
Complete proteome
FMN
Flavoprotein
Oxidoreductase
Peroxisome
Phosphoprotein
Polymorphism
Reference proteome