Names & Taxonomy

Uniprot ID:
Q9NYQ3
Entry Name:
HAOX2_HUMAN
Status:
reviewed
Protein Names:
Hydroxyacid oxidase 2 (HAOX2) (EC 1.1.3.15) ((S)-2-hydroxy-acid oxidase, peroxisomal) (Cell growth-inhibiting gene 16 protein) (Long chain alpha-hydroxy acid oxidase) (Long-chain L-2-hydroxy acid oxidase)
Gene Names:
HAO2 HAOX2 GIG16
Gene Names Orf:
GIG16
Gene Names Primary:
HAO2
Organism:
Homo sapiens (Human)

Structure

Length:
351
Sequence:
MSLVCLTDFQAHAREQLSKSTRDFIEGGADDSITRDDNIAAFKRIRLRPRYLRDVSEVDTRTTIQGEEISAPICIAPTGFHCLVWPDGEMSTARAAQAAGICYITSTFASCSLEDIVIAAPEGLRWFQLYVHPDLQLNKQLIQRVESLGFKALVITLDTPVCGNRRHDIRNQLRRNLTLTDLQSPKKGNAIPYFQMTPISTSLCWNDLSWFQSITRLPIILKGILTKEDAELAVKHNVQGIIVSNHGGRQLDEVLASIDALTEVVAAVKGKIEVYLDGGVRTGNDVLKALALGAKCIFLGRPILWGLACKGEHGVKEVLNILTNEFHTSMALTGCRSVAEINRNLVQFSRL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Peroxisome.

Function

Function:
Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.
Catalytic Activity:
(S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2).
Cofactor:
COFACTOR: Name=FMN; Xref=ChEBI:CHEBI:58210;
Active Site:
ACT_SITE 246 246 Proton acceptor.
Gene Ontology Go:
extracellular exosome
mitochondrion
peroxisomal matrix
peroxisome
(S)-2-hydroxy-acid oxidase activity
FMN binding
long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
medium-chain-(S)-2-hydroxy-acid oxidase activity
receptor binding
very-long-chain-(S)-2-hydroxy-acid oxidase activity
cellular lipid metabolic process
fatty acid oxidation
small molecule metabolic process
Gene Ontology Biological Process:
cellular lipid metabolic process
fatty acid oxidation
small molecule metabolic process
Gene Ontology Molecular Function:
(S)-2-hydroxy-acid oxidase activity
FMN binding
long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
medium-chain-(S)-2-hydroxy-acid oxidase activity
receptor binding
very-long-chain-(S)-2-hydroxy-acid oxidase activity
Gene Ontology Cellular Component:
extracellular exosome
mitochondrion
peroxisomal matrix
peroxisome
Keywords:
Alternative splicing
Complete proteome
FMN
Flavoprotein
Oxidoreductase
Peroxisome
Phosphoprotein
Polymorphism
Reference proteome

Publication

PubMed ID:
10777549 14702039 16710414 15489334 24275569