Names & Taxonomy

Uniprot ID:
Q9NY65
Entry Name:
TBA8_HUMAN
Status:
reviewed
Protein Names:
Tubulin alpha-8 chain (Alpha-tubulin 8) (Tubulin alpha chain-like 2)
Gene Names:
TUBA8 TUBAL2
Gene Names Primary:
TUBA8
Organism:
Homo sapiens (Human)

Structure

Length:
449
Sequence:
MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFDAQASKINDDDSFTTFFSETGNGKHVPRAVMIDLEPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLTDACSGLQGFLIFHSFGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLSVAEITSSCFEPNSQMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGTDSFEEENEGEEF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytoskeleton.

Function

Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Gene Ontology Go:
cytoplasm
microtubule
GTP binding
GTPase activity
structural constituent of cytoskeleton
'de novo' posttranslational protein folding
cellular protein metabolic process
microtubule-based process
protein folding
Gene Ontology Biological Process:
'de novo' posttranslational protein folding
cellular protein metabolic process
microtubule-based process
protein folding
Gene Ontology Molecular Function:
GTPase activity
GTP binding
structural constituent of cytoskeleton
Gene Ontology Cellular Component:
cytoplasm
microtubule
Keywords:
Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
GTP-binding
Microtubule
Nucleotide-binding
Polymorphism
Reference proteome

Publication

PubMed ID:
10772959 15461802 14702039 10591208 15489334 19896110 19524510 20466094 26875866