Names & Taxonomy
- Uniprot ID:
- Q9NY65
- Entry Name:
- TBA8_HUMAN
- Status:
- reviewed
- Protein Names:
- Tubulin alpha-8 chain (Alpha-tubulin 8) (Tubulin alpha chain-like 2)
- Gene Names:
- TUBA8 TUBAL2
- Gene Names Primary:
- TUBA8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 449
- Sequence:
- MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFDAQASKINDDDSFTTFFSETGNGKHVPRAVMIDLEPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLTDACSGLQGFLIFHSFGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLSVAEITSSCFEPNSQMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGTDSFEEENEGEEF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton.
Function
- Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
- Gene Ontology Go:
- cytoplasm
microtubule
GTP binding
GTPase activity
structural constituent of cytoskeleton
'de novo' posttranslational protein folding
cellular protein metabolic process
microtubule-based process
protein folding - Gene Ontology Biological Process:
- 'de novo' posttranslational protein folding
cellular protein metabolic process
microtubule-based process
protein folding - Gene Ontology Molecular Function:
- GTPase activity
GTP binding
structural constituent of cytoskeleton - Gene Ontology Cellular Component:
- cytoplasm
microtubule - Keywords:
- Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
GTP-binding
Microtubule
Nucleotide-binding
Polymorphism
Reference proteome