Names & Taxonomy
- Uniprot ID:
- Q9NVM4
- Entry Name:
- ANM7_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein arginine N-methyltransferase 7 (EC 2.1.1.321) (Histone-arginine N-methyltransferase PRMT7) ([Myelin basic protein]-arginine N-methyltransferase PRMT7)
- Gene Names:
- PRMT7 KIAA1933
- Gene Names Primary:
- PRMT7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 692
- Sequence:
- MKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRNVKYYQGIRAAVSRVKDRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVINKHSTEVTVGPEGDMPCRANILVTELFDTELIGEGALPSYEHAHRHLVEENCEAVPHRATVYAQLVESGRMWSWNKLFPIHVQTSLGEQVIVPPVDVESCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSIDFSKQVSSSAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAPFWAHSDPEEMQWRDHWMQCVYFLPQEEPVVQGSALYLVAHHDDYCVWYSLQRTSPEKNERVRQMRPVCDCQAHLLWNRPRFGEINDQDRTDRYVQALRTVLKPDSVCLCVSDGSLLSVLAHHLGVEQVFTVESSAASHKLLRKIFKANHLEDKINIIEKRPELLTNEDLQGRKVSLLLGEPFFTTSLLPWHNLYFWYVRTAVDQHLGPGAMVMPQAASLHAVVVEFRDLWRIRSPCGDCEGFDVHIMDDMIKRALDFRESREAEPHPLWEYPCRSLSEPWQILTFDFQQPVPLQPLCAEGTVELRRPGQSHAAVLWMEYHLTPECTLSTGLLEPADPEGGCCWNPHCKQAVYFFSPAPDPRALLGGPRTVSYAVEFHPDTGDIIMEFRHADTPD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytosol
Function
- Function:
- Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
- Catalytic Activity:
- S-adenosyl-L-methionine + -L-arginine = S-adenosyl-L-homocysteine + -N(omega)-methyl-L-arginine.
- Active Site:
- ACT_SITE 144 144
- Gene Ontology Go:
- cytosol
nucleolus
nucleoplasm
nucleus
-arginine N-methyltransferase activity
histone binding
histone methyltransferase activity (H4-R3 specific)
histone-arginine N-methyltransferase activity
protein-arginine omega-N asymmetric methyltransferase activity
protein-arginine omega-N monomethyltransferase activity
protein-arginine omega-N symmetric methyltransferase activity
ribonucleoprotein complex binding
S-adenosylmethionine-dependent methyltransferase activity
cell differentiation
chromatin organization
DNA methylation involved in gamete generation
histone arginine methylation
histone methylation
peptidyl-arginine methylation
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
peptidyl-arginine methylation, to symmetrical-dimethyl arginine
peptidyl-arginine N-methylation
peptidyl-arginine omega-N-methylation
regulation of gene expression by genetic imprinting
regulation of protein binding
regulation of transcription, DNA-templated
spliceosomal snRNP assembly
transcription, DNA-templated - Gene Ontology Biological Process:
- cell differentiation
chromatin organization
DNA methylation involved in gamete generation
histone arginine methylation
histone methylation
peptidyl-arginine methylation
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
peptidyl-arginine methylation, to symmetrical-dimethyl arginine
peptidyl-arginine N-methylation
peptidyl-arginine omega-N-methylation
regulation of gene expression by genetic imprinting
regulation of protein binding
regulation of transcription, DNA-templated
spliceosomal snRNP assembly
transcription, DNA-templated - Gene Ontology Molecular Function:
- -arginine N-methyltransferase activity
histone-arginine N-methyltransferase activity
histone binding
histone methyltransferase activity (H4-R3 specific)
protein-arginine omega-N asymmetric methyltransferase activity
protein-arginine omega-N monomethyltransferase activity
protein-arginine omega-N symmetric methyltransferase activity
ribonucleoprotein complex binding
S-adenosylmethionine-dependent methyltransferase activity - Gene Ontology Cellular Component:
- cytosol
nucleolus
nucleoplasm
nucleus - Keywords:
- Alternative splicing
Chromatin regulator
Complete proteome
Cytoplasm
Differentiation
Methyltransferase
Nucleus
Reference proteome
Repeat
S-adenosyl-L-methionine
Transcription
Transcription regulation
Transferase