Names & Taxonomy
- Uniprot ID:
- Q9NUN5
- Entry Name:
- LMBD1_HUMAN
- Status:
- reviewed
- Protein Names:
- Probable lysosomal cobalamin transporter (HDAg-L-interacting protein NESI) (LMBR1 domain-containing protein 1) (Nuclear export signal-interacting protein)
- Gene Names:
- LMBRD1 C6orf209 NESI BM-021 CD001 MSTP044
- Gene Names Orf:
- BM-021 CD001 MSTP044
- Gene Names Primary:
- LMBRD1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 540
- Sequence:
- MATSGAASAELVIGWCIFGLLLLAILAFCWIYVRKYQSRRESEVVSTITAIFSLAIALITSALLPVDIFLVSYMKNQNGTFKDWANANVSRQIEDTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDDDDTSKCTQIKTALKYTLGFVVICALLLLVGAFVPLNVPNNKNSTEWEKVKSLFEELGSSHGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSAAYERLENTEDIEEVEQHIQTIKSKSKDGRPLPARDKRALKQFEERLRTLKKRERHLEFIENSWWTKFCGALRPLKIVWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIIFGANLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIETNITSDNHKGNSTLSVPKRCDADAPEDQCTVTRTYLFLHKFWFFSAAYYFGNWAFLGVFLIGLIVSCCKGKKSVIEGVDEDSDISDDEPSVYSA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome membrane
Function
- Function:
- Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV).
- Gene Ontology Go:
- clathrin-coated endocytic vesicle
integral component of membrane
lysosomal membrane
membrane
plasma membrane
cobalamin binding
cobalamin metabolic process
insulin receptor internalization
negative regulation of glucose import
negative regulation of insulin receptor signaling pathway
negative regulation of protein kinase B signaling
small molecule metabolic process
viral process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- cobalamin metabolic process
insulin receptor internalization
negative regulation of glucose import
negative regulation of insulin receptor signaling pathway
negative regulation of protein kinase B signaling
small molecule metabolic process
viral process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- cobalamin binding
- Gene Ontology Cellular Component:
- clathrin-coated endocytic vesicle
integral component of membrane
lysosomal membrane
membrane
plasma membrane - Keywords:
- Alternative splicing
Cobalamin
Cobalt
Complete proteome
Glycoprotein
Host-virus interaction
Lysosome
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport