Names & Taxonomy

Uniprot ID:
Q9NUB1
Entry Name:
ACS2L_HUMAN
Status:
reviewed
Protein Names:
Acetyl-coenzyme A synthetase 2-like, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1)
Gene Names:
ACSS1 ACAS2L KIAA1846
Gene Names Primary:
ACSS1
Organism:
Homo sapiens (Human)

Structure

Length:
689
Sequence:
MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPGSYPALSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVRKSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELGDTTTLEDPSIIAEILSVYQKCKDKQAAAK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion matrix

Function

Function:
Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).
Catalytic Activity:
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
Enzyme Regulation:
ENZYME REGULATION: Inhibited by acetylation at Lys-642 and activated by deacetylation.
Cross Reference Drug Bank:
DB00131 DB00171
Gene Ontology Go:
mitochondrial matrix
acetate-CoA ligase activity
AMP binding
ATP binding
acetate biosynthetic process
acetyl-CoA biosynthetic process
acetyl-CoA biosynthetic process from acetate
ethanol oxidation
propionate biosynthetic process
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
acetate biosynthetic process
acetyl-CoA biosynthetic process
acetyl-CoA biosynthetic process from acetate
ethanol oxidation
propionate biosynthetic process
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
acetate-CoA ligase activity
AMP binding
ATP binding
Gene Ontology Cellular Component:
mitochondrial matrix
Keywords:
3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Ligase
Mitochondrion
Nucleotide-binding
Polymorphism
Reference proteome
Transit peptide
Interacts With:
Q08AM6

Publication

PubMed ID:
14702039 11780052 15489334 11347906 12168954 16788062 19608861 21269460 25944712 19535340