Names & Taxonomy
- Uniprot ID:
- Q9NUB1
- Entry Name:
- ACS2L_HUMAN
- Status:
- reviewed
- Protein Names:
- Acetyl-coenzyme A synthetase 2-like, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1)
- Gene Names:
- ACSS1 ACAS2L KIAA1846
- Gene Names Primary:
- ACSS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 689
- Sequence:
- MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPGSYPALSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVRKSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELGDTTTLEDPSIIAEILSVYQKCKDKQAAAK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix
Function
- Function:
- Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).
- Catalytic Activity:
- ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by acetylation at Lys-642 and activated by deacetylation.
- Cross Reference Drug Bank:
- DB00131 DB00171
- Gene Ontology Go:
- mitochondrial matrix
acetate-CoA ligase activity
AMP binding
ATP binding
acetate biosynthetic process
acetyl-CoA biosynthetic process
acetyl-CoA biosynthetic process from acetate
ethanol oxidation
propionate biosynthetic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- acetate biosynthetic process
acetyl-CoA biosynthetic process
acetyl-CoA biosynthetic process from acetate
ethanol oxidation
propionate biosynthetic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- acetate-CoA ligase activity
AMP binding
ATP binding - Gene Ontology Cellular Component:
- mitochondrial matrix
- Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Ligase
Mitochondrion
Nucleotide-binding
Polymorphism
Reference proteome
Transit peptide - Interacts With:
- Q08AM6