Names & Taxonomy
- Uniprot ID:
- Q9NS75
- Entry Name:
- CLTR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Cysteinyl leukotriene receptor 2 (CysLTR2) (G-protein coupled receptor GPCR21) (hGPCR21) (G-protein coupled receptor HG57) (HPN321)
- Gene Names:
- CYSLTR2 CYSLT2 CYSLT2R PSEC0146
- Gene Names Orf:
- PSEC0146
- Gene Names Primary:
- CYSLTR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 346
- Sequence:
- MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
- Cross Reference Drug Bank:
- DB00716
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
cysteinyl leukotriene receptor activity
G-protein coupled peptide receptor activity
leukotriene receptor activity
immune response
neuropeptide signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of angiogenesis
positive regulation of cell death
positive regulation of ERK1 and ERK2 cascade - Gene Ontology Biological Process:
- immune response
neuropeptide signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of angiogenesis
positive regulation of cell death
positive regulation of ERK1 and ERK2 cascade - Gene Ontology Molecular Function:
- cysteinyl leukotriene receptor activity
G-protein coupled peptide receptor activity
leukotriene receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- Q9Y271