Names & Taxonomy
- Uniprot ID:
- Q9NRE1
- Entry Name:
- MMP26_HUMAN
- Status:
- reviewed
- Protein Names:
- Matrix metalloproteinase-26 (MMP-26) (EC 3.4.24.-) (Endometase) (Matrilysin-2)
- Gene Names:
- MMP26
- Gene Names Primary:
- MMP26
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 261
- Sequence:
- MQLVILRVTIFLPWCFAVPVPPAADHKGWDFVEGYFHQFFLTKKESPLLTQETQTQLLQQFHRNGTDLLDMQMHALLHQPHCGVPDGSDTSISPGRCKWNKHTLTYRIINYPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQVQNGDADIKVSFWQWAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFDKNEHWSASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQRIQHLYGEKCSSDIP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix.
Function
- Function:
- May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 209 209
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- proteinaceous extracellular matrix
metalloendopeptidase activity
zinc ion binding
collagen catabolic process
negative regulation of inflammatory response
proteolysis - Gene Ontology Biological Process:
- collagen catabolic process
negative regulation of inflammatory response
proteolysis - Gene Ontology Molecular Function:
- metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- proteinaceous extracellular matrix
- Keywords:
- Calcium
Collagen degradation
Complete proteome
Extracellular matrix
Glycoprotein
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Secreted
Signal
Zinc
Zymogen