Names & Taxonomy
- Uniprot ID:
- Q9NRA2
- Entry Name:
- S17A5_HUMAN
- Status:
- reviewed
- Protein Names:
- Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter)
- Gene Names:
- SLC17A5
- Gene Names Primary:
- SLC17A5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 495
- Sequence:
- MRSPVRDLARNDGEESTDRTPLLPGAPRAEAAPVCCSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKGEVQNWALNDHHGHRH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.
- Gene Ontology Go:
- cell junction
cytoplasm
integral component of plasma membrane
lysosomal membrane
membrane
plasma membrane
synaptic vesicle membrane
sialic acid transmembrane transporter activity
sugar:proton symporter activity
amino acid transport
anion transport
carboxylic acid transmembrane transport
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
ion transport
post-translational protein modification
protein N-linked glycosylation via asparagine
proton transport
sialic acid transport
transmembrane transport - Gene Ontology Biological Process:
- amino acid transport
anion transport
carboxylic acid transmembrane transport
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
ion transport
post-translational protein modification
protein N-linked glycosylation via asparagine
proton transport
sialic acid transport
transmembrane transport - Gene Ontology Molecular Function:
- sialic acid transmembrane transporter activity
sugar:proton symporter activity - Gene Ontology Cellular Component:
- cell junction
cytoplasm
integral component of plasma membrane
lysosomal membrane
membrane
plasma membrane
synaptic vesicle membrane - Keywords:
- Alternative splicing
Amino-acid transport
Cell junction
Cell membrane
Complete proteome
Cytoplasmic vesicle
Disease mutation
Glycoprotein
Lysosome
Membrane
Reference proteome
Symport
Synapse
Transmembrane
Transmembrane helix
Transport