Names & Taxonomy
- Uniprot ID:
- Q9NR19
- Entry Name:
- ACSA_HUMAN
- Status:
- reviewed
- Protein Names:
- Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme)
- Gene Names:
- ACSS2 ACAS2
- Gene Names Primary:
- ACSS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 701
- Sequence:
- MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPREFWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Activates acetate so that it can be used for lipid synthesis or for energy generation.
- Catalytic Activity:
- ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
- Cross Reference Drug Bank:
- DB00131 DB00171
- Gene Ontology Go:
- cytoplasm
cytosol
intracellular membrane-bounded organelle
nucleoplasm
acetate-CoA ligase activity
AMP binding
ATP binding
acetate biosynthetic process
acetyl-CoA biosynthetic process from acetate
ethanol oxidation
lipid biosynthetic process
propionate biosynthetic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- acetate biosynthetic process
acetyl-CoA biosynthetic process from acetate
ethanol oxidation
lipid biosynthetic process
propionate biosynthetic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- acetate-CoA ligase activity
AMP binding
ATP binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
intracellular membrane-bounded organelle
nucleoplasm - Keywords:
- ATP-binding
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Ligase
Nucleotide-binding
Phosphoprotein
Reference proteome