Names & Taxonomy
- Uniprot ID:
- Q9NQW7
- Entry Name:
- XPP1_HUMAN
- Status:
- reviewed
- Protein Names:
- Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble)
- Gene Names:
- XPNPEP1 XPNPEPL XPNPEPL1
- Gene Names Primary:
- XPNPEP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 623
- Sequence:
- MPPKVTSELLRQLRQAMRNSEYVTEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSAGTAIITEEHAAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAGHHLIPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKDKVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGDRIDAPSVKEHLLLDLGLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKASYAVSETIPKDHRCCMPYTPICIAKAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKELQKQGRQEALEWLIRETQPISKQH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.
- Catalytic Activity:
- Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
- Cofactor:
- COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=100.6 uM for bradykinin
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by apstatin and the metal ion chelators EDTA and 1,10-phenanthroline. Partially inhibited by dithiothreitol. Not inhibited by enalaprilat or amastatin.
- Gene Ontology Go:
- cytoplasm
extracellular exosome
aminopeptidase activity
manganese ion binding
metalloaminopeptidase activity
protein homodimerization activity
bradykinin catabolic process
proteolysis - Gene Ontology Biological Process:
- bradykinin catabolic process
proteolysis - Gene Ontology Molecular Function:
- aminopeptidase activity
manganese ion binding
metalloaminopeptidase activity
protein homodimerization activity - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Aminopeptidase
Complete proteome
Cytoplasm
Direct protein sequencing
Hydrolase
Manganese
Metal-binding
Metalloprotease
Protease
Reference proteome