Names & Taxonomy
- Uniprot ID:
- Q9NQS7
- Entry Name:
- INCE_HUMAN
- Status:
- reviewed
- Protein Names:
- Inner centromere protein
- Gene Names:
- INCENP
- Gene Names Primary:
- INCENP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 918
- Sequence:
- MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSPPLQGARVPSSLAYSLKKH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1.
- Gene Ontology Go:
- central element
chromocenter
chromosome, centromeric region
condensed chromosome kinetochore
cytosol
kinetochore
lateral element
microtubule
midbody
nucleoplasm
pericentric heterochromatin
protein complex
spindle
cellular protein metabolic process
chromosome segregation
cytokinesis
mitotic cell cycle
mitotic nuclear division
post-translational protein modification
protein sumoylation
small GTPase mediated signal transduction - Gene Ontology Biological Process:
- cellular protein metabolic process
chromosome segregation
cytokinesis
mitotic cell cycle
mitotic nuclear division
post-translational protein modification
protein sumoylation
small GTPase mediated signal transduction - Gene Ontology Cellular Component:
- central element
chromocenter
chromosome, centromeric region
condensed chromosome kinetochore
cytosol
kinetochore
lateral element
microtubule
midbody
nucleoplasm
pericentric heterochromatin
protein complex
spindle - Keywords:
- 3D-structure
Alternative splicing
Cell cycle
Cell division
Centromere
Chromosome
Chromosome partition
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Kinetochore
Microtubule
Mitosis
Nucleus
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- Q96GD4; O15392; P45973; Q53HL2