Names & Taxonomy

Uniprot ID:
Q9NQS7
Entry Name:
INCE_HUMAN
Status:
reviewed
Protein Names:
Inner centromere protein
Gene Names:
INCENP
Gene Names Primary:
INCENP
Organism:
Homo sapiens (Human)

Structure

Length:
918
Sequence:
MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSPPLQGARVPSSLAYSLKKH
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus

Function

Function:
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1.
Gene Ontology Go:
central element
chromocenter
chromosome, centromeric region
condensed chromosome kinetochore
cytosol
kinetochore
lateral element
microtubule
midbody
nucleoplasm
pericentric heterochromatin
protein complex
spindle
cellular protein metabolic process
chromosome segregation
cytokinesis
mitotic cell cycle
mitotic nuclear division
post-translational protein modification
protein sumoylation
small GTPase mediated signal transduction
Gene Ontology Biological Process:
cellular protein metabolic process
chromosome segregation
cytokinesis
mitotic cell cycle
mitotic nuclear division
post-translational protein modification
protein sumoylation
small GTPase mediated signal transduction
Gene Ontology Cellular Component:
central element
chromocenter
chromosome, centromeric region
condensed chromosome kinetochore
cytosol
kinetochore
lateral element
microtubule
midbody
nucleoplasm
pericentric heterochromatin
protein complex
spindle
Keywords:
3D-structure
Alternative splicing
Cell cycle
Cell division
Centromere
Chromosome
Chromosome partition
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Kinetochore
Microtubule
Mitosis
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Interacts With:
Q96GD4; O15392; P45973; Q53HL2

Publication

PubMed ID:
11453556 15316025 16554811 15489334 9864353 11139336 12925766 14610074 15249581 17081983 16764853 16760428 18220336 18691976 18669648 19413330 19369195 19690332 20562864 20068231 21225229 21406692 17956729