Names & Taxonomy
- Uniprot ID:
- Q9NQ94
- Entry Name:
- A1CF_HUMAN
- Status:
- reviewed
- Protein Names:
- APOBEC1 complementation factor (APOBEC1-stimulating protein)
- Gene Names:
- A1CF ACF ASP
- Gene Names Primary:
- A1CF
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 594
- Sequence:
- MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDAAPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKVEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMARRKLLPGRIQLWGHGIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNNIKPGAVERVKKIRDYAFVHFSNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRGTMLQGEYTYSLGQVYDPTTTYLGAPVFYAPQTYAAIPSLHFPATKGHLSNRAIIRAPSVREIYMNVPVGAAGVRGLGGRGYLAYTGLGRGYQVKGDKREDKLYDILPGMELTPMNPVTLKPQGIKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKITIPALASQNPAIHPFTPPKLSAFVDEAKTYAAEYTLQTLGIPTDGGDGTMATAAAAATAFPGYAVPNATAPVSAAQLKQAVTLGQDLAAYTTYEVYPTFAVTARGDGYGTF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.
- Gene Ontology Go:
- apolipoprotein B mRNA editing enzyme complex
cytoplasm
endoplasmic reticulum
nucleoplasm
nucleotide binding
RNA binding
single-stranded RNA binding
cytidine to uridine editing
gene expression
mRNA modification
mRNA processing
protein stabilization - Gene Ontology Biological Process:
- cytidine to uridine editing
gene expression
mRNA modification
mRNA processing
protein stabilization - Gene Ontology Molecular Function:
- nucleotide binding
RNA binding
single-stranded RNA binding - Gene Ontology Cellular Component:
- apolipoprotein B mRNA editing enzyme complex
cytoplasm
endoplasmic reticulum
nucleoplasm - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Endoplasmic reticulum
Nucleus
Phosphoprotein
Polymorphism
RNA-binding
Reference proteome
Repeat
mRNA processing - Interacts With:
- Q13643; Q04864; O95810; Q13077