Names & Taxonomy
- Uniprot ID:
- Q9NPH3
- Entry Name:
- IL1AP_HUMAN
- Status:
- reviewed
- Protein Names:
- Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)
- Gene Names:
- IL1RAP C3orf13 IL1R3
- Gene Names Primary:
- IL1RAP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 570
- Sequence:
- MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKSPRRSSSDEQGLSYSSLKNV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.; Isoform 3: Secreted.
Function
- Function:
- Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system.
- Gene Ontology Go:
- cytoplasm
extracellular region
integral component of plasma membrane
membrane
plasma membrane
protein complex
interleukin-1 receptor activity
signal transducer activity
immune response
inflammatory response
innate immune response
protein complex assembly - Gene Ontology Biological Process:
- immune response
inflammatory response
innate immune response
protein complex assembly - Gene Ontology Molecular Function:
- interleukin-1 receptor activity
signal transducer activity - Gene Ontology Cellular Component:
- cytoplasm
extracellular region
integral component of plasma membrane
membrane
plasma membrane
protein complex - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Immunity
Immunoglobulin domain
Inflammatory response
Innate immunity
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix