Names & Taxonomy

Uniprot ID:
Q9NPH3
Entry Name:
IL1AP_HUMAN
Status:
reviewed
Protein Names:
Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)
Gene Names:
IL1RAP C3orf13 IL1R3
Gene Names Primary:
IL1RAP
Organism:
Homo sapiens (Human)

Structure

Length:
570
Sequence:
MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKSPRRSSSDEQGLSYSSLKNV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.; Isoform 3: Secreted.

Function

Function:
Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system.
Gene Ontology Go:
cytoplasm
extracellular region
integral component of plasma membrane
membrane
plasma membrane
protein complex
interleukin-1 receptor activity
signal transducer activity
immune response
inflammatory response
innate immune response
protein complex assembly
Gene Ontology Biological Process:
immune response
inflammatory response
innate immune response
protein complex assembly
Gene Ontology Molecular Function:
interleukin-1 receptor activity
signal transducer activity
Gene Ontology Cellular Component:
cytoplasm
extracellular region
integral component of plasma membrane
membrane
plasma membrane
protein complex
Keywords:
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Immunity
Immunoglobulin domain
Inflammatory response
Innate immunity
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
9371760 10799889 12781872 17949817 19481478 16641997 15489334 9479509 9862719 12659850 12530978 18669648 19369195 19690332 19836339 20805474 20068231 22723552 23479569 25595648 20802483