Names & Taxonomy

Uniprot ID:
Q9NPB1
Entry Name:
NT5M_HUMAN
Status:
reviewed
Protein Names:
5'(3')-deoxyribonucleotidase, mitochondrial (5',3'-nucleotidase, mitochondrial) (EC 3.1.3.-) (Deoxy-5'-nucleotidase 2) (dNT-2)
Gene Names:
NT5M DNT2
Gene Names Primary:
NT5M
Organism:
Homo sapiens (Human)

Structure

Length:
228
Sequence:
MIRLGGWCARRLCSAAVPAGRRGAAGGLGLAGGRALRVLVDMDGVLADFEGGFLRKFRARFPDQPFIALEDRRGFWVSEQYGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMASLQNTDVFICTSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDITGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion

Function

Function:
Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Active Site:
ACT_SITE 41 41 Nucleophile.; ACT_SITE 43 43 Proton donor.
Gene Ontology Go:
mitochondrial matrix
mitochondrion
5'-nucleotidase activity
metal ion binding
nucleotidase activity
nucleotide binding
dephosphorylation
DNA replication
dUMP catabolic process
nucleobase-containing small molecule metabolic process
pyrimidine deoxyribonucleotide catabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
small molecule metabolic process
Gene Ontology Biological Process:
dephosphorylation
DNA replication
dUMP catabolic process
nucleobase-containing small molecule metabolic process
pyrimidine deoxyribonucleotide catabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
5'-nucleotidase activity
metal ion binding
nucleotidase activity
nucleotide binding
Gene Ontology Cellular Component:
mitochondrial matrix
mitochondrion
Keywords:
3D-structure
Complete proteome
Hydrolase
Magnesium
Metal-binding
Mitochondrion
Nucleotide metabolism
Nucleotide-binding
Reference proteome
Transit peptide

Publication

PubMed ID:
10899995 15489334 12352955