Names & Taxonomy
- Uniprot ID:
- Q9NPA2
- Entry Name:
- MMP25_HUMAN
- Status:
- reviewed
- Protein Names:
- Matrix metalloproteinase-25 (MMP-25) (EC 3.4.24.-) (Leukolysin) (Membrane-type matrix metalloproteinase 6) (MT-MMP 6) (MTMMP6) (Membrane-type-6 matrix metalloproteinase) (MT6-MMP) (MT6MMP)
- Gene Names:
- MMP25 MMP20 MMPL1 MT6MMP
- Gene Names Primary:
- MMP25
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 562
- Sequence:
- MRLRLRLLALLLLLLAPPARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGGARPLTELGLPPGEEVDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPSSGPRAPRPPKATPVSETCDCQCELNQAAGRWPAPIPLLLLPLLVGGVASR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.
Function
- Function:
- May activate progelatinase A.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 234 234
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- anchored component of membrane
integral component of membrane
membrane
plasma membrane
proteinaceous extracellular matrix
calcium ion binding
metalloendopeptidase activity
zinc ion binding
hard palate development
inflammatory response
proteolysis - Gene Ontology Biological Process:
- hard palate development
inflammatory response
proteolysis - Gene Ontology Molecular Function:
- calcium ion binding
metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- anchored component of membrane
integral component of membrane
membrane
plasma membrane
proteinaceous extracellular matrix - Keywords:
- Calcium
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Disulfide bond
Extracellular matrix
GPI-anchor
Glycoprotein
Hydrolase
Lipoprotein
Membrane
Metal-binding
Metalloprotease
Protease
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen