Names & Taxonomy
- Uniprot ID:
- Q9NP91
- Entry Name:
- S6A20_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium- and chloride-dependent transporter XTRP3 (Sodium/imino-acid transporter 1) (Solute carrier family 6 member 20) (Transporter rB21A homolog)
- Gene Names:
- SLC6A20 SIT1 XT3 XTRP3
- Gene Names Primary:
- SLC6A20
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 592
- Sequence:
- MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKRGDADPVA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane
Function
- Function:
- Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. Involved in the transport of glycine.
- Gene Ontology Go:
- apical plasma membrane
integral component of plasma membrane
plasma membrane
amino acid transmembrane transporter activity
glycine:sodium symporter activity
neurotransmitter:sodium symporter activity
amino acid transmembrane transport
amino acid transport
glycine import
glycine transport
ion transport
proline transport
synaptic transmission, glycinergic
transmembrane transport - Gene Ontology Biological Process:
- amino acid transmembrane transport
amino acid transport
glycine import
glycine transport
ion transport
proline transport
synaptic transmission, glycinergic
transmembrane transport - Gene Ontology Molecular Function:
- amino acid transmembrane transporter activity
glycine:sodium symporter activity
neurotransmitter:sodium symporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Amino-acid transport
Cell membrane
Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q6UY14-3; P60370; P60409; P60410; P60411; Q7Z3S9