Names & Taxonomy

Uniprot ID:
Q9NP91
Entry Name:
S6A20_HUMAN
Status:
reviewed
Protein Names:
Sodium- and chloride-dependent transporter XTRP3 (Sodium/imino-acid transporter 1) (Solute carrier family 6 member 20) (Transporter rB21A homolog)
Gene Names:
SLC6A20 SIT1 XT3 XTRP3
Gene Names Primary:
SLC6A20
Organism:
Homo sapiens (Human)

Structure

Length:
592
Sequence:
MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKRGDADPVA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Apical cell membrane

Function

Function:
Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. Involved in the transport of glycine.
Gene Ontology Go:
apical plasma membrane
integral component of plasma membrane
plasma membrane
amino acid transmembrane transporter activity
glycine:sodium symporter activity
neurotransmitter:sodium symporter activity
amino acid transmembrane transport
amino acid transport
glycine import
glycine transport
ion transport
proline transport
synaptic transmission, glycinergic
transmembrane transport
Gene Ontology Biological Process:
amino acid transmembrane transport
amino acid transport
glycine import
glycine transport
ion transport
proline transport
synaptic transmission, glycinergic
transmembrane transport
Gene Ontology Molecular Function:
amino acid transmembrane transporter activity
glycine:sodium symporter activity
neurotransmitter:sodium symporter activity
Gene Ontology Cellular Component:
apical plasma membrane
integral component of plasma membrane
plasma membrane
Keywords:
Alternative splicing
Amino-acid transport
Cell membrane
Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport
Interacts With:
Q6UY14-3; P60370; P60409; P60410; P60411; Q7Z3S9

Publication

PubMed ID:
11352561 15489334 9932288 15632147 19033659