Names & Taxonomy
- Uniprot ID:
- Q9HCK4
- Entry Name:
- ROBO2_HUMAN
- Status:
- reviewed
- Protein Names:
- Roundabout homolog 2
- Gene Names:
- ROBO2 KIAA1568
- Gene Names Primary:
- ROBO2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1378
- Sequence:
- MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLSDGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASSPAISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEEALVPYSKPSFPSPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIGYMGSNSQGQFTGEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.
- Gene Ontology Go:
- axolemma
cell surface
extracellular exosome
integral component of membrane
axon guidance receptor activity
identical protein binding
apoptotic process involved in luteolysis
axon guidance
axon midline choice point recognition
brain development
cellular response to hormone stimulus
central nervous system development
homophilic cell adhesion via plasma membrane adhesion molecules
metanephros development
negative regulation of negative chemotaxis
negative regulation of synapse assembly
olfactory bulb interneuron development
positive regulation of axonogenesis
retinal ganglion cell axon guidance
Roundabout signaling pathway
ureteric bud development - Gene Ontology Biological Process:
- apoptotic process involved in luteolysis
axon guidance
axon midline choice point recognition
brain development
cellular response to hormone stimulus
central nervous system development
homophilic cell adhesion via plasma membrane adhesion molecules
metanephros development
negative regulation of negative chemotaxis
negative regulation of synapse assembly
olfactory bulb interneuron development
positive regulation of axonogenesis
retinal ganglion cell axon guidance
Roundabout signaling pathway
ureteric bud development - Gene Ontology Molecular Function:
- axon guidance receptor activity
identical protein binding - Gene Ontology Cellular Component:
- axolemma
cell surface
extracellular exosome
integral component of membrane - Keywords:
- 3D-structure
Alternative splicing
Chemotaxis
Chromosomal rearrangement
Complete proteome
Developmental protein
Differentiation
Disease mutation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Neurogenesis
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix