Names & Taxonomy
- Uniprot ID:
- Q9HCD5
- Entry Name:
- NCOA5_HUMAN
- Status:
- reviewed
- Protein Names:
- Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA)
- Gene Names:
- NCOA5 KIAA1637
- Gene Names Primary:
- NCOA5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 579
- Sequence:
- MNTAPSRPSPTRRDPYGFGDSRDSRRDRSPIRGSPRREPRDGRNGRDARDSRDIRDPRDLRDHRHSRDLRDHRDSRSVRDVRDVRDLRDFRDLRDSRDFRDQRDPMYDRYRDMRDSRDPMYRREGSYDRYLRMDDYCRRKDDSYFDRYRDSFDGRGPPGPESQSRAKERLKREERRREELYRQYFEEIQRRFDAERPVDCSVIVVNKQTKDYAESVGRKVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQEHRNMPQADAMVLVARNYERYKNECREKEREEIARQAAKMADEAILQERERGGPEEGVRGGHPPAIQSLINLLADNRYLTAEETDKIINYLRERKERLMRSSTDSLPGPISRQPLGATSGASLKTQPSSQPLQSGQVLPSATPTPSAPPTSQQELQAKILSLFNSGTVTANSSSASPSVAAGNTPNQNFSTAANSQPQQRSQASGNQPPSILGQGGSAQNMGPRPGAPSQGLFGQPSSRLAPASNMTSQRPVSSTGINFDNPSVQKALDTLIQSGPALSHLVSQTTAQMGQPQAPMGSYQRHY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus.
Function
- Function:
- Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).
- Gene Ontology Go:
- actin cytoskeleton
extracellular space
nucleus
chromatin binding
poly(A) RNA binding
glucose homeostasis
negative regulation of insulin receptor signaling pathway
regulation of transcription, DNA-templated
transcription, DNA-templated - Gene Ontology Biological Process:
- glucose homeostasis
negative regulation of insulin receptor signaling pathway
regulation of transcription, DNA-templated
transcription, DNA-templated - Gene Ontology Molecular Function:
- chromatin binding
poly(A) RNA binding - Gene Ontology Cellular Component:
- actin cytoskeleton
extracellular space
nucleus - Keywords:
- 3D-structure
Acetylation
Activator
Complete proteome
Direct protein sequencing
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repressor
Transcription
Transcription regulation - Interacts With:
- Q60674