Names & Taxonomy
- Uniprot ID:
- Q9HC58
- Entry Name:
- NCKX3_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/potassium/calcium exchanger 3 (Na(+)/K(+)/Ca(2+)-exchange protein 3) (Solute carrier family 24 member 3)
- Gene Names:
- SLC24A3 NCKX3
- Gene Names Primary:
- SLC24A3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 644
- Sequence:
- MRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLLLYGVFLCFSIMTEFNVFTFVNLPMCGDH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
calcium channel activity
calcium ion binding
calcium, potassium:sodium antiporter activity
potassium ion binding
sodium ion binding
symporter activity
calcium ion transmembrane transport
cellular calcium ion homeostasis
ion transport
sodium ion transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- calcium ion transmembrane transport
cellular calcium ion homeostasis
ion transport
sodium ion transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- calcium, potassium:sodium antiporter activity
calcium channel activity
calcium ion binding
potassium ion binding
sodium ion binding
symporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Antiport
Calcium
Calcium transport
Complete proteome
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Potassium
Potassium transport
Reference proteome
Repeat
Signal
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport