Names & Taxonomy

Uniprot ID:
Q9HBH1
Entry Name:
DEFM_HUMAN
Status:
reviewed
Protein Names:
Peptide deformylase, mitochondrial (EC 3.5.1.88) (Polypeptide deformylase)
Gene Names:
PDF PDF1A
Gene Names Primary:
PDF
Organism:
Homo sapiens (Human)

Structure

Length:
243
Sequence:
MARLWGALSLWPLWAAVPWGGAAAVGVRACSSTAAPDGVEGPALRRSYWRHLRRLVLGPPEPPFSHVCQVGDPVLRGVAAPVERAQLGGPELQRLTQRLVQVMRRRRCVGLSAPQLGVPRQVLALELPEALCRECPPRQRALRQMEPFPLRVFVNPSLRVLDSRLVTFPEGCESVAGFLACVPRFQAVQISGLDPNGEQVVWQASGWAARIIQHEMDHLQGCLFIDKMDSRTFTNVYWMKVND
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion

Function

Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins.
Catalytic Activity:
Formyl-L-methionyl peptide + H(2)O = formate + methionyl peptide.
Cofactor:
COFACTOR: Name=Co(2+); Xref=ChEBI:CHEBI:48828;
Active Site:
ACT_SITE 215 215
Gene Ontology Go:
mitochondrion
iron ion binding
peptide deformylase activity
N-terminal protein amino acid modification
peptidyl-methionine modification
positive regulation of cell proliferation
translation
Gene Ontology Biological Process:
N-terminal protein amino acid modification
peptidyl-methionine modification
positive regulation of cell proliferation
translation
Gene Ontology Molecular Function:
iron ion binding
peptide deformylase activity
Gene Ontology Cellular Component:
mitochondrion
Keywords:
3D-structure
Cobalt
Complete proteome
Hydrolase
Metal-binding
Mitochondrion
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide

Publication

PubMed ID:
11060042 15489334 14532271 21269460 25944712 19236878