Names & Taxonomy
- Uniprot ID:
- Q9HBH1
- Entry Name:
- DEFM_HUMAN
- Status:
- reviewed
- Protein Names:
- Peptide deformylase, mitochondrial (EC 3.5.1.88) (Polypeptide deformylase)
- Gene Names:
- PDF PDF1A
- Gene Names Primary:
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 243
- Sequence:
- MARLWGALSLWPLWAAVPWGGAAAVGVRACSSTAAPDGVEGPALRRSYWRHLRRLVLGPPEPPFSHVCQVGDPVLRGVAAPVERAQLGGPELQRLTQRLVQVMRRRRCVGLSAPQLGVPRQVLALELPEALCRECPPRQRALRQMEPFPLRVFVNPSLRVLDSRLVTFPEGCESVAGFLACVPRFQAVQISGLDPNGEQVVWQASGWAARIIQHEMDHLQGCLFIDKMDSRTFTNVYWMKVND
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion
Function
- Function:
- Removes the formyl group from the N-terminal Met of newly synthesized proteins.
- Catalytic Activity:
- Formyl-L-methionyl peptide + H(2)O = formate + methionyl peptide.
- Cofactor:
- COFACTOR: Name=Co(2+); Xref=ChEBI:CHEBI:48828;
- Active Site:
- ACT_SITE 215 215
- Gene Ontology Go:
- mitochondrion
iron ion binding
peptide deformylase activity
N-terminal protein amino acid modification
peptidyl-methionine modification
positive regulation of cell proliferation
translation - Gene Ontology Biological Process:
- N-terminal protein amino acid modification
peptidyl-methionine modification
positive regulation of cell proliferation
translation - Gene Ontology Molecular Function:
- iron ion binding
peptide deformylase activity - Gene Ontology Cellular Component:
- mitochondrion
- Keywords:
- 3D-structure
Cobalt
Complete proteome
Hydrolase
Metal-binding
Mitochondrion
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide