Names & Taxonomy
- Uniprot ID:
- Q9HBG4
- Entry Name:
- VPP4_HUMAN
- Status:
- reviewed
- Protein Names:
- V-type proton ATPase 116 kDa subunit a isoform 4 (V-ATPase 116 kDa isoform a4) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4) (Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform)
- Gene Names:
- ATP6V0A4 ATP6N1B ATP6N2
- Gene Names Primary:
- ATP6V0A4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 840
- Sequence:
- MVSVFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLERILRFLEDEMQNEIVVQLLEKSPLTPLPREMITLETVLEKLEGELQEANQNQQALKQSFLELTELKYLLKKTQDFFETETNLADDFFTEDTSGLLELKAVPAYMTGKLGFIAGVINRERMASFERLLWRICRGNVYLKFSEMDAPLEDPVTKEEIQKNIFIIFYQGEQLRQKIKKICDGFRATVYPCPEPAVERREMLESVNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQKMKAVYHILNMCNIDVTQQCVIAEIWFPVADATRIKRALEQGMELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIITFPFLFAVMFGDCGHGTVMLLAALWMILNERRLLSQKTDNEIWNTFFHGRYLILLMGIFSIYTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWNTHVMEESLYLQLDPAIPGVYFGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIVQMVFGVILSLFNHIYFRRTLNIILQFIPEMIFILCLFGYLVFMIIFKWCCFDVHVSQHAPSILIHFINMFLFNYSDSSNAPLYKHQQEVQSFFVVMALISVPWMLLIKPFILRASHRKSQLQASRIQEDATENIEGDSSSPSSRSGQRTSADTHGALDDHGEEFNFGDVFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVMNSGLQTRGWGGIVGVFIIFAVFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKFYVGDGYKFSPFSFKHILDGTAEE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane; Multi-pass membrane protein. Note=Present at high density almost exclusively on the apical surface of alpha-intercalated cells in the cortical collecting ducts of the distal nephron.
Function
- Function:
- Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney.
- Gene Ontology Go:
- apical part of cell
apical plasma membrane
brush border membrane
endosome
endosome membrane
extracellular exosome
integral component of membrane
lysosomal membrane
phagocytic vesicle membrane
plasma membrane
vacuolar proton-transporting V-type ATPase, V0 domain
ATPase binding
proton-transporting ATPase activity, rotational mechanism
ATP hydrolysis coupled proton transport
ATP synthesis coupled proton transport
cell redox homeostasis
cellular iron ion homeostasis
excretion
insulin receptor signaling pathway
ion transmembrane transport
ossification
proton transport
regulation of pH
sensory perception of sound
transferrin transport
transmembrane transport
vacuolar acidification
vacuolar proton-transporting V-type ATPase complex assembly - Gene Ontology Biological Process:
- ATP hydrolysis coupled proton transport
ATP synthesis coupled proton transport
cell redox homeostasis
cellular iron ion homeostasis
excretion
insulin receptor signaling pathway
ion transmembrane transport
ossification
proton transport
regulation of pH
sensory perception of sound
transferrin transport
transmembrane transport
vacuolar acidification
vacuolar proton-transporting V-type ATPase complex assembly - Gene Ontology Molecular Function:
- ATPase binding
proton-transporting ATPase activity, rotational mechanism - Gene Ontology Cellular Component:
- apical part of cell
apical plasma membrane
brush border membrane
endosome
endosome membrane
extracellular exosome
integral component of membrane
lysosomal membrane
phagocytic vesicle membrane
plasma membrane
vacuolar proton-transporting V-type ATPase, V0 domain - Keywords:
- Cell membrane
Complete proteome
Disease mutation
Hydrogen ion transport
Ion transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport