Names & Taxonomy

Uniprot ID:
Q9HBA0
Entry Name:
TRPV4_HUMAN
Status:
reviewed
Protein Names:
Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC)
Gene Names:
TRPV4 VRL2 VROAC
Gene Names Primary:
TRPV4
Organism:
Homo sapiens (Human)

Structure

Length:
871
Sequence:
MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDNKRWRKKIIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEASVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDEVVVPLDSMGNPRCDGHQQGYPRKWRTDDAPL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Apical cell membrane
Intramembrane:
INTRAMEM 648 678 Pore-forming.

Function

Function:
Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040). Also activated by heat, low pH, citrate and phorbol esters (PubMed:18826956, PubMed:18695040). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity).
Gene Ontology Go:
adherens junction
apical plasma membrane
cell surface
cilium
cortical actin cytoskeleton
cytoplasmic microtubule
cytoplasmic vesicle
filopodium
focal adhesion
growth cone
integral component of membrane
lamellipodium
plasma membrane
ruffle membrane
actin binding
actin filament binding
alpha-tubulin binding
ATP binding
beta-tubulin binding
calcium channel activity
calmodulin binding
cation channel activity
microtubule binding
osmosensor activity
protein kinase binding
protein kinase C binding
SH2 domain binding
stretch-activated, cation-selective, calcium channel activity
actin cytoskeleton reorganization
actin filament organization
blood vessel endothelial cell delamination
calcium ion import
calcium ion transmembrane transport
calcium ion transport
cell volume homeostasis
cell-cell junction assembly
cellular calcium ion homeostasis
cellular hypotonic response
cellular hypotonic salinity response
cellular response to heat
cellular response to osmotic stress
cortical microtubule organization
diet induced thermogenesis
glucose homeostasis
hyperosmotic salinity response
ion transmembrane transport
microtubule polymerization
multicellular organismal water homeostasis
negative regulation of brown fat cell differentiation
negative regulation of neuron projection development
negative regulation of transcription from RNA polymerase II promoter
osmosensory signaling pathway
positive regulation of chemokine (C-C motif) ligand 5 production
positive regulation of chemokine (C-X-C motif) ligand 1 production
positive regulation of cytosolic calcium ion concentration
positive regulation of energy homeostasis
positive regulation of ERK1 and ERK2 cascade
positive regulation of gene expression
positive regulation of inflammatory response
positive regulation of interleukin-6 secretion
positive regulation of JNK cascade
positive regulation of macrophage chemotaxis
positive regulation of macrophage inflammatory protein 1 alpha production
positive regulation of microtubule depolymerization
positive regulation of monocyte chemotactic protein-1 production
positive regulation of vascular permeability
regulation of response to osmotic stress
response to insulin
response to mechanical stimulus
signal transduction involved in regulation of aerobic respiration
transmembrane transport
vasopressin secretion
Gene Ontology Biological Process:
actin cytoskeleton reorganization
actin filament organization
blood vessel endothelial cell delamination
calcium ion import
calcium ion transmembrane transport
calcium ion transport
cell-cell junction assembly
cellular calcium ion homeostasis
cellular hypotonic response
cellular hypotonic salinity response
cellular response to heat
cellular response to osmotic stress
cell volume homeostasis
cortical microtubule organization
diet induced thermogenesis
glucose homeostasis
hyperosmotic salinity response
ion transmembrane transport
microtubule polymerization
multicellular organismal water homeostasis
negative regulation of brown fat cell differentiation
negative regulation of neuron projection development
negative regulation of transcription from RNA polymerase II promoter
osmosensory signaling pathway
positive regulation of chemokine (C-C motif) ligand 5 production
positive regulation of chemokine (C-X-C motif) ligand 1 production
positive regulation of cytosolic calcium ion concentration
positive regulation of energy homeostasis
positive regulation of ERK1 and ERK2 cascade
positive regulation of gene expression
positive regulation of inflammatory response
positive regulation of interleukin-6 secretion
positive regulation of JNK cascade
positive regulation of macrophage chemotaxis
positive regulation of macrophage inflammatory protein 1 alpha production
positive regulation of microtubule depolymerization
positive regulation of monocyte chemotactic protein-1 production
positive regulation of vascular permeability
regulation of response to osmotic stress
response to insulin
response to mechanical stimulus
signal transduction involved in regulation of aerobic respiration
transmembrane transport
vasopressin secretion
Gene Ontology Molecular Function:
actin binding
actin filament binding
alpha-tubulin binding
ATP binding
beta-tubulin binding
calcium channel activity
calmodulin binding
cation channel activity
microtubule binding
osmosensor activity
protein kinase binding
protein kinase C binding
SH2 domain binding
stretch-activated, cation-selective, calcium channel activity
Gene Ontology Cellular Component:
adherens junction
apical plasma membrane
cell surface
cilium
cortical actin cytoskeleton
cytoplasmic microtubule
cytoplasmic vesicle
filopodium
focal adhesion
growth cone
integral component of membrane
lamellipodium
plasma membrane
ruffle membrane
Keywords:
3D-structure
ANK repeat
ATP-binding
Alternative splicing
Calcium
Calcium channel
Calcium transport
Calmodulin-binding
Cell junction
Cell membrane
Cell projection
Charcot-Marie-Tooth disease
Cilium
Complete proteome
Disease mutation
Dwarfism
Ion channel
Ion transport
Membrane
Neurodegeneration
Neuropathy
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
11081638 11025659 12692122 16293632 15489334 12724311 18826956 18695040 19759329 19666518 22328087 22702953 18587396 19232556 20425821 20503319 20577006 20037588 20037587 20037586 21115951 21964574 21288981 22526352