Names & Taxonomy

Uniprot ID:
Q9HB55
Entry Name:
CP343_HUMAN
Status:
reviewed
Protein Names:
Cytochrome P450 3A43 (EC 1.14.14.1)
Gene Names:
CYP3A43
Gene Names Primary:
CYP3A43
Organism:
Homo sapiens (Human)

Structure

Length:
503
Sequence:
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRDGITSGP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Function

Function:
Exhibits low testosterone 6-beta-hydroxylase activity.
Catalytic Activity:
RH + + O(2) = ROH + + H(2)O.
Cofactor:
COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
Cross Reference Drug Bank:
DB05239 DB09102 DB01234 DB08930 DB00593 DB09048 DB00842 DB00780 DB01058 DB01045 DB01201 DB00624 DB01361 DB00943
Gene Ontology Go:
endoplasmic reticulum membrane
aromatase activity
heme binding
iron ion binding
monooxygenase activity
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
aromatase activity
heme binding
iron ion binding
monooxygenase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
Keywords:
Alternative splicing
Complete proteome
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
Oxidoreductase
Polymorphism
Reference proteome

Publication

PubMed ID:
11160876 11243885 11266076 14695544 12853948 15489334 11726664 14759258