Names & Taxonomy
- Uniprot ID:
- Q9H9Y6
- Entry Name:
- RPA2_HUMAN
- Status:
- reviewed
- Protein Names:
- DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135)
- Gene Names:
- POLR1B
- Gene Names Primary:
- POLR1B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1135
- Sequence:
- MDPGSRWRNLPSGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAVHEGLGLAVQAIPPFEFAFKDERISFTILDAVISPPTVPKGTICKEANVYPAECRGRRSTYRGKLTADINWAVNGISKGIIKQFLGYVPIMVKSKLCNLRNLPPQALIEHHEEAEEMGGYFIINGIEKVIRMLIMPRRNFPIAMIRPKWKTRGPGYTQYGVSMHCVREEHSAVNMNLHYLENGTVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSFLRNSVSQMLRIVMEEGCSTQKQVLNYLGECFRVKLNVPDWYPNEQAAEFLFNQCICIHLKSNTEKFYMLCLMTRKLFALAKGECMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGWLVSIKIAFDKKAQKTSVSMNTDNLMRIFTMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLCVVADKLNFIRYLSHFRCVHRGADFAKMRTTTVRRLLPESWGFLCPVHTPDGEPCGLMNHLTAVCEVVTQFVYTASIPALLCNLGVTPIDGAPHRSYSECYPVLLDGVMVGWVDKDLAPGIADSLRHFKVLREKRIPPWMEVVLIPMTGKPSLYPGLFLFTTPCRLVRPVQNLALGKEELIGTMEQIFMNVAIFEDEVFAGVTTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYRLQTPQSPLVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFIDLSEKIKQGDSSLVFGIKPGDPRVLQKLDDDGLPFIGAKLQYGDPYYSYLNLNTGESFVMYYKSKENCVVDNIKVCSNDTGSGKFKCVCITMRVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMVPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYSGISGLELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDRVTNQPIGGRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAHVCVKCGSLLSPLLEKPPPSWSAMRNRKYNCTLCSRSDTIDTVSVPYVFRYFVAELAAMNIKVKLDVV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus, nucleolus
Function
- Function:
- DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
- Catalytic Activity:
- Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
- Gene Ontology Go:
- cytoplasm
DNA-directed RNA polymerase I complex
nucleolus
nucleoplasm
DNA binding
DNA-directed RNA polymerase activity
metal ion binding
ribonucleoside binding
embryo implantation
gene expression
negative regulation of gene expression, epigenetic
nucleologenesis
positive regulation of gene expression, epigenetic
regulation of gene expression, epigenetic
rRNA transcription
termination of RNA polymerase I transcription
transcription elongation from RNA polymerase I promoter
transcription from RNA polymerase I promoter
transcription initiation from RNA polymerase I promoter - Gene Ontology Biological Process:
- embryo implantation
gene expression
negative regulation of gene expression, epigenetic
nucleologenesis
positive regulation of gene expression, epigenetic
regulation of gene expression, epigenetic
rRNA transcription
termination of RNA polymerase I transcription
transcription elongation from RNA polymerase I promoter
transcription from RNA polymerase I promoter
transcription initiation from RNA polymerase I promoter - Gene Ontology Molecular Function:
- DNA binding
DNA-directed RNA polymerase activity
metal ion binding
ribonucleoside binding - Gene Ontology Cellular Component:
- cytoplasm
DNA-directed RNA polymerase I complex
nucleolus
nucleoplasm - Keywords:
- Alternative splicing
Complete proteome
DNA-directed RNA polymerase
Metal-binding
Nucleotidyltransferase
Nucleus
Polymorphism
Reference proteome
Transcription
Transferase
Zinc
Zinc-finger - Interacts With:
- O95602