Names & Taxonomy
- Uniprot ID:
- A0A024R2K6
- Entry Name:
- A0A024R2K6_HUMAN
- Status:
- unreviewed
- Protein Names:
- Calcium-transporting ATPase (EC 3.6.3.8)
- Gene Names:
- ATP2B2 hCG_1811446
- Gene Names Orf:
- hCG_1811446
- Gene Names Primary:
- ATP2B2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1243
- Sequence:
- MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKGVKKGDGLQLPAADGAAASNAADSANASLVNGKMQDGNVDASQSKAKQQDGAAAMEMQPLKSAEGGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
- Catalytic Activity:
- ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
- Gene Ontology Go:
- apical plasma membrane
cilium
endoplasmic reticulum
integral component of membrane
neuronal cell body
ATP binding
calcium-dependent ATPase activity
calcium-transporting ATPase activity
metal ion binding
auditory receptor cell stereocilium organization
cerebellar granule cell differentiation
cerebellar Purkinje cell differentiation
cGMP metabolic process
cochlea development
detection of mechanical stimulus involved in sensory perception of sound
lactation
locomotion
locomotory behavior
neuromuscular process controlling balance
organelle organization
otolith mineralization
positive regulation of calcium ion transport
regulation of cell size
regulation of cytosolic calcium ion concentration
regulation of synaptic plasticity
serotonin metabolic process
synapse organization - Gene Ontology Biological Process:
- auditory receptor cell stereocilium organization
cerebellar granule cell differentiation
cerebellar Purkinje cell differentiation
cGMP metabolic process
cochlea development
detection of mechanical stimulus involved in sensory perception of sound
lactation
locomotion
locomotory behavior
neuromuscular process controlling balance
organelle organization
otolith mineralization
positive regulation of calcium ion transport
regulation of cell size
regulation of cytosolic calcium ion concentration
regulation of synaptic plasticity
serotonin metabolic process
synapse organization - Gene Ontology Molecular Function:
- ATP binding
calcium-dependent ATPase activity
calcium-transporting ATPase activity
metal ion binding - Gene Ontology Cellular Component:
- apical plasma membrane
cilium
endoplasmic reticulum
integral component of membrane
neuronal cell body - Keywords:
- ATP-binding
Calcium
Calcium transport
Hydrolase
Ion transport
Membrane
Nucleotide-binding
Transmembrane
Transmembrane helix
Transport
Publication
- PubMed ID:
- 11181995