Names & Taxonomy
- Uniprot ID:
- Q9H6R6
- Entry Name:
- ZDHC6_HUMAN
- Status:
- reviewed
- Protein Names:
- Palmitoyltransferase ZDHHC6 (EC 2.3.1.225) (Transmembrane protein H4) (Zinc finger DHHC domain-containing protein 6) (DHHC-6) (Zinc finger protein 376)
- Gene Names:
- ZDHHC6 ZNF376
- Gene Names Primary:
- ZDHHC6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 413
- Sequence:
- MGTFCSVIKFENLQELKRLCHWGPIIALGVIAICSTMAMIDSVLWYWPLHTTGGSVNFIMLINWTVMILYNYFNAMFVGPGFVPLGWKPEISQDTMYLQYCKVCQAYKAPRSHHCRKCNRCVMKMDHHCPWINNCCGYQNHASFTLFLLLAPLGCIHAAFIFVMTMYTQLYHRLSFGWNTVKIDMSAARRDPLPIVPFGLAAFATTLFALGLALGTTIAVGMLFFIQMKIILRNKTSIESWIEEKAKDRIQYYQLDEVFVFPYDMGSRWRNFKQVFTWSGVPEGDGLEWPVREGCHQYSLTIEQLKQKADKRVRSVRYKVIEDYSGACCPLNKGIKTFFTSPCTEEPRIQLQKGEFILATRGLRYWLYGDKILDDSFIEGVSRIRGWFPRKCVEKCPCDAETDQAPEGEKKNR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins.
- Catalytic Activity:
- Palmitoyl-CoA + -L-cysteine = -S-palmitoyl-L-cysteine + CoA.
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
palmitoyltransferase activity
protein-cysteine S-palmitoyltransferase activity
zinc ion binding
protein palmitoylation - Gene Ontology Biological Process:
- protein palmitoylation
- Gene Ontology Molecular Function:
- palmitoyltransferase activity
protein-cysteine S-palmitoyltransferase activity
zinc ion binding - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Acyltransferase
Alternative splicing
Complete proteome
Endoplasmic reticulum
Membrane
Metal-binding
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix
Zinc
Zinc-finger