Names & Taxonomy

Uniprot ID:
Q9H6R6
Entry Name:
ZDHC6_HUMAN
Status:
reviewed
Protein Names:
Palmitoyltransferase ZDHHC6 (EC 2.3.1.225) (Transmembrane protein H4) (Zinc finger DHHC domain-containing protein 6) (DHHC-6) (Zinc finger protein 376)
Gene Names:
ZDHHC6 ZNF376
Gene Names Primary:
ZDHHC6
Organism:
Homo sapiens (Human)

Structure

Length:
413
Sequence:
MGTFCSVIKFENLQELKRLCHWGPIIALGVIAICSTMAMIDSVLWYWPLHTTGGSVNFIMLINWTVMILYNYFNAMFVGPGFVPLGWKPEISQDTMYLQYCKVCQAYKAPRSHHCRKCNRCVMKMDHHCPWINNCCGYQNHASFTLFLLLAPLGCIHAAFIFVMTMYTQLYHRLSFGWNTVKIDMSAARRDPLPIVPFGLAAFATTLFALGLALGTTIAVGMLFFIQMKIILRNKTSIESWIEEKAKDRIQYYQLDEVFVFPYDMGSRWRNFKQVFTWSGVPEGDGLEWPVREGCHQYSLTIEQLKQKADKRVRSVRYKVIEDYSGACCPLNKGIKTFFTSPCTEEPRIQLQKGEFILATRGLRYWLYGDKILDDSFIEGVSRIRGWFPRKCVEKCPCDAETDQAPEGEKKNR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins.
Catalytic Activity:
Palmitoyl-CoA + -L-cysteine = -S-palmitoyl-L-cysteine + CoA.
Gene Ontology Go:
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
palmitoyltransferase activity
protein-cysteine S-palmitoyltransferase activity
zinc ion binding
protein palmitoylation
Gene Ontology Biological Process:
protein palmitoylation
Gene Ontology Molecular Function:
palmitoyltransferase activity
protein-cysteine S-palmitoyltransferase activity
zinc ion binding
Gene Ontology Cellular Component:
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
Keywords:
Acyltransferase
Alternative splicing
Complete proteome
Endoplasmic reticulum
Membrane
Metal-binding
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix
Zinc
Zinc-finger

Publication

PubMed ID:
14702039 15489334 22314232