Names & Taxonomy
- Uniprot ID:
- Q9H4B7
- Entry Name:
- TBB1_HUMAN
- Status:
- reviewed
- Protein Names:
- Tubulin beta-1 chain
- Gene Names:
- TUBB1
- Gene Names Primary:
- TUBB1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 451
- Sequence:
- MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVSEYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton
Function
- Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
- Cross Reference Drug Bank:
- DB06772 DB01394 DB01248 DB01229 DB00309
- Gene Ontology Go:
- cytoplasm
extracellular exosome
microtubule
GTP binding
GTPase activity
structural constituent of cytoskeleton
'de novo' posttranslational protein folding
cellular protein metabolic process
protein folding
spindle assembly - Gene Ontology Biological Process:
- 'de novo' posttranslational protein folding
cellular protein metabolic process
protein folding
spindle assembly - Gene Ontology Molecular Function:
- GTPase activity
GTP binding
structural constituent of cytoskeleton - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
microtubule - Keywords:
- Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
GTP-binding
Isopeptide bond
Microtubule
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome