Names & Taxonomy

Uniprot ID:
Q9H4B7
Entry Name:
TBB1_HUMAN
Status:
reviewed
Protein Names:
Tubulin beta-1 chain
Gene Names:
TUBB1
Gene Names Primary:
TUBB1
Organism:
Homo sapiens (Human)

Structure

Length:
451
Sequence:
MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVSEYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytoskeleton

Function

Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Cross Reference Drug Bank:
DB06772 DB01394 DB01248 DB01229 DB00309
Gene Ontology Go:
cytoplasm
extracellular exosome
microtubule
GTP binding
GTPase activity
structural constituent of cytoskeleton
'de novo' posttranslational protein folding
cellular protein metabolic process
protein folding
spindle assembly
Gene Ontology Biological Process:
'de novo' posttranslational protein folding
cellular protein metabolic process
protein folding
spindle assembly
Gene Ontology Molecular Function:
GTPase activity
GTP binding
structural constituent of cytoskeleton
Gene Ontology Cellular Component:
cytoplasm
extracellular exosome
microtubule
Keywords:
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
GTP-binding
Isopeptide bond
Microtubule
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome

Publication

PubMed ID:
11780052 15489334 12665801 18347012 19524510 20191564 26875866 15956286 18849486