Names & Taxonomy
- Uniprot ID:
- Q9H244
- Entry Name:
- P2Y12_HUMAN
- Status:
- reviewed
- Protein Names:
- P2Y purinoceptor 12 (P2Y12) (ADP-glucose receptor) (ADPG-R) (P2T(AC)) (P2Y(AC)) (P2Y(cyc)) (P2Y12 platelet ADP receptor) (P2Y(ADP)) (SP1999)
- Gene Names:
- P2RY12 HORK3
- Gene Names Primary:
- P2RY12
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 342
- Sequence:
- MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.
- Cross Reference Drug Bank:
- DB06441 DB00758 DB01240 DB06209 DB08816 DB00208 DB00374
- Gene Ontology Go:
- basal plasma membrane
caveola
cell surface
external side of plasma membrane
integral component of plasma membrane
intrinsic component of membrane
mitochondrion
plasma membrane
ADP receptor activity
G-protein coupled adenosine receptor activity
guanyl-nucleotide exchange factor activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
blood coagulation
calcium ion transmembrane transport
cellular response to ATP
G-protein coupled receptor signaling pathway
glial cell migration
hemostasis
negative regulation of cell differentiation
negative regulation of norepinephrine secretion
platelet activation
platelet aggregation
positive regulation of GTPase activity
positive regulation of ion transport
potassium ion transmembrane transport
protein kinase B signaling
regulation of calcium ion transport
regulation of microglial cell migration
substrate-dependent cell migration, cell extension - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
blood coagulation
calcium ion transmembrane transport
cellular response to ATP
glial cell migration
G-protein coupled receptor signaling pathway
hemostasis
negative regulation of cell differentiation
negative regulation of norepinephrine secretion
platelet activation
platelet aggregation
positive regulation of GTPase activity
positive regulation of ion transport
potassium ion transmembrane transport
protein kinase B signaling
regulation of calcium ion transport
regulation of microglial cell migration
substrate-dependent cell migration, cell extension - Gene Ontology Molecular Function:
- ADP receptor activity
G-protein coupled adenosine receptor activity
guanyl-nucleotide exchange factor activity - Gene Ontology Cellular Component:
- basal plasma membrane
caveola
cell surface
external side of plasma membrane
integral component of plasma membrane
intrinsic component of membrane
mitochondrion
plasma membrane - Keywords:
- 3D-structure
Blood coagulation
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
G-protein coupled receptor
Glycoprotein
Hemostasis
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix