Names & Taxonomy
- Uniprot ID:
- Q9H1N7
- Entry Name:
- S35B3_HUMAN
- Status:
- reviewed
- Protein Names:
- Adenosine 3'-phospho 5'-phosphosulfate transporter 2 (3'-phosphoadenosine 5'-phosphosulfate transporter) (PAPS transporter 2) (Solute carrier family 35 member B3)
- Gene Names:
- SLC35B3 C6orf196 PAPST2 CGI-19
- Gene Names Orf:
- CGI-19
- Gene Names Primary:
- SLC35B3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 401
- Sequence:
- MDLTQQAKDIQNITVQETNKNNSESIECSKITMDLKFNNSRKYISITVPSKTQTMSPHIKSVDDVVVLGMNLSKFNKLTQFFICVAGVFVFYLIYGYLQELIFSVEGFKSCGWYLTLVQFAFYSIFGLIELQLIQDKRRRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYNVADVSAAICMSLGLIWFTLADSTTAPNFNLTGVVLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLGLTCTSGLGPAVTFCAKNPVRTYGYAFLFSLTGYFGISFVLALIKIFGALIAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGLLVVLGIFLNVYSKNMDKIRLPSLYDLINKSVEARKSRTLAQTV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus membrane
Function
- Function:
- Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=2.2 uM for PAPS
- Gene Ontology Go:
- Golgi membrane
integral component of membrane
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
3'-phosphoadenosine 5'-phosphosulfate metabolic process
carbohydrate metabolic process
glycosaminoglycan metabolic process
mitophagy in response to mitochondrial depolarization
positive regulation of defense response to virus by host
small molecule metabolic process
transmembrane transport
xenobiotic metabolic process
xenophagy - Gene Ontology Biological Process:
- 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
3'-phosphoadenosine 5'-phosphosulfate metabolic process
carbohydrate metabolic process
glycosaminoglycan metabolic process
mitophagy in response to mitochondrial depolarization
positive regulation of defense response to virus by host
small molecule metabolic process
transmembrane transport
xenobiotic metabolic process
xenophagy - Gene Ontology Cellular Component:
- Golgi membrane
integral component of membrane - Keywords:
- Alternative splicing
Complete proteome
Glycoprotein
Golgi apparatus
Membrane
Reference proteome
Transmembrane
Transmembrane helix
Transport