Names & Taxonomy
- Uniprot ID:
- Q9H1D0
- Entry Name:
- TRPV6_HUMAN
- Status:
- reviewed
- Protein Names:
- Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2)
- Gene Names:
- TRPV6 ECAC2
- Gene Names Primary:
- TRPV6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 765
- Sequence:
- MGPLQGDGGPALGGADVAPRLSPVRVWPRPQAPKEPALHPMGLSLPKEKGLILCLWSKFCRWFQRRESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDLTEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRTSPRDNTLLQQKLLQEAYMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTILGGPFHVLIITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDYPMALFSTFELFLTIIDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVATTVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIQRYAQAFHTRGSEDLDKDSVEKLELGCPFSPHLSLPMPSVSRSTSRSSANWERLRQGTLRRDLRGIINRGLEDGESWEYQI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
- Intramembrane:
- INTRAMEM 564 584 Pore-forming.
Function
- Function:
- Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).
- Gene Ontology Go:
- extracellular exosome
integral component of plasma membrane
plasma membrane
calcium channel activity
calmodulin binding
calcium ion transmembrane transport
calcium ion transport
ion transmembrane transport
regulation of calcium ion-dependent exocytosis
transmembrane transport - Gene Ontology Biological Process:
- calcium ion transmembrane transport
calcium ion transport
ion transmembrane transport
regulation of calcium ion-dependent exocytosis
transmembrane transport - Gene Ontology Molecular Function:
- calcium channel activity
calmodulin binding - Gene Ontology Cellular Component:
- extracellular exosome
integral component of plasma membrane
plasma membrane - Keywords:
- ANK repeat
Alternative splicing
Calcium
Calcium channel
Calcium transport
Calmodulin-binding
Cell membrane
Complete proteome
Glycoprotein
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P18031