Names & Taxonomy
- Uniprot ID:
- Q9BZV2
- Entry Name:
- S19A3_HUMAN
- Status:
- reviewed
- Protein Names:
- Thiamine transporter 2 (ThTr-2) (ThTr2) (Solute carrier family 19 member 3)
- Gene Names:
- SLC19A3
- Gene Names Primary:
- SLC19A3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 496
- Sequence:
- MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKNLTSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGISFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKPSREIKKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWDLLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVERYALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMRSMYITYSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Mediates high affinity thiamine uptake, propably via a proton anti-port mechanism. Has no folate transport activity.
- Cross Reference Drug Bank:
- DB00151
- Gene Ontology Go:
- integral component of membrane
integral component of plasma membrane
plasma membrane
thiamine uptake transmembrane transporter activity
small molecule metabolic process
thiamine transmembrane transport
thiamine-containing compound metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- small molecule metabolic process
thiamine-containing compound metabolic process
thiamine transmembrane transport
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- thiamine uptake transmembrane transporter activity
- Gene Ontology Cellular Component:
- integral component of membrane
integral component of plasma membrane
plasma membrane - Keywords:
- Complete proteome
Disease mutation
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport