Names & Taxonomy
- Uniprot ID:
- Q9BZP6
- Entry Name:
- CHIA_HUMAN
- Status:
- reviewed
- Protein Names:
- Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Lung-specific protein TSA1902)
- Gene Names:
- CHIA
- Gene Names Primary:
- CHIA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 476
- Sequence:
- MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Secreted. Note=Secretion depends on EGFR activity.; Isoform 2: Cytoplasm.; Isoform 3: Cytoplasm.
Function
- Function:
- Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.
- Catalytic Activity:
- Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.
- Active Site:
- ACT_SITE 140 140 Proton donor.
- Gene Ontology Go:
- cytoplasm
extracellular region
extracellular space
carbohydrate binding
chitin binding
chitinase activity
kinase binding
lysozyme activity
apoptotic process
carbohydrate metabolic process
cell wall chitin metabolic process
chitin catabolic process
chitin metabolic process
digestion
immune response
polysaccharide catabolic process
positive regulation of chemokine secretion
production of molecular mediator involved in inflammatory response
response to fungus
small molecule metabolic process - Gene Ontology Biological Process:
- apoptotic process
carbohydrate metabolic process
cell wall chitin metabolic process
chitin catabolic process
chitin metabolic process
digestion
immune response
polysaccharide catabolic process
positive regulation of chemokine secretion
production of molecular mediator involved in inflammatory response
response to fungus
small molecule metabolic process - Gene Ontology Molecular Function:
- carbohydrate binding
chitinase activity
chitin binding
kinase binding
lysozyme activity - Gene Ontology Cellular Component:
- cytoplasm
extracellular region
extracellular space - Keywords:
- 3D-structure
Alternative splicing
Apoptosis
Carbohydrate metabolism
Chitin degradation
Chitin-binding
Complete proteome
Cytoplasm
Disulfide bond
Glycosidase
Hydrolase
Immunity
Inflammatory response
Polymorphism
Polysaccharide degradation
Reference proteome
Secreted
Signal