Names & Taxonomy
- Uniprot ID:
- Q9BXS0
- Entry Name:
- COPA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Collagen alpha-1(XXV) chain (Alzheimer disease amyloid-associated protein) (AMY) (CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component (CLAC)]
- Gene Names:
- COL25A1
- Gene Names Primary:
- COL25A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 654
- Sequence:
- MLLKKHAGKGGGREPRSEDPTPAEQHCARTMPPCAVLAALLSVVAVVSCLYLGVKTNDLQARIAALESAKGAPSIHLLPDTLDHLKTMVQEKVERLLAQKSYEHMAKIRIAREAPSECNCPAGPPGKRGKRGRRGESGPPGQPGPQGPPGPKGDKGEQGDQGPRMVFPKINHGFLSADQQLIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPRGMPGVPGEPGKPGEQGLMGPLGPPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQNGIPGPKGEPGEQGEKGDAGENGPKGDTGEKGDPGSSAAGIKGEPGESGRPGQKGEPGLPGLPGLPGIKGEPGFIGPQGEPGLPGLPGTKGERGEAGPPGRGERGEPGAPGPKGKQGESGTRGPKGSKGDRGEKGDSGAQGPRGPPGQKGDQGATEIIDYNGNLHEALQRITTLTVTGPPGPPGPQGLQGPKGEQGSPGIPGMDGEQGLKGSKGDMGDPGMTGEKGGIGLPGLPGANGMKGEKGDSGMPGPQGPSIIGPPGPPGPHGPPGPMGPHGLPGPKGTDGPMGPHGPAGPKGERGEKGAMGEPGPRGPYGLPGKDGEPGLDGFPGPRGEKGDLGEKGEKGFRGVKGEKGEPGQPGLDGLDAPCQLGPDGLPMPGCWQK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
- Gene Ontology Go:
- collagen trimer
endoplasmic reticulum lumen
extracellular region
extracellular space
integral component of membrane
integral component of plasma membrane
plasma membrane
beta-amyloid binding
heparin binding
axonogenesis involved in innervation
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization - Gene Ontology Biological Process:
- axonogenesis involved in innervation
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization - Gene Ontology Molecular Function:
- beta-amyloid binding
heparin binding - Gene Ontology Cellular Component:
- collagen trimer
endoplasmic reticulum lumen
extracellular region
extracellular space
integral component of membrane
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Amyloid
Collagen
Complete proteome
Direct protein sequencing
Disease mutation
Glycoprotein
Heparin-binding
Hydroxylation
Membrane
Pyrrolidone carboxylic acid
Reference proteome
Repeat
Signal-anchor
Transmembrane
Transmembrane helix