Names & Taxonomy

Uniprot ID:
Q9BVJ7
Entry Name:
DUS23_HUMAN
Status:
reviewed
Protein Names:
Dual specificity protein phosphatase 23 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z)
Gene Names:
DUSP23 LDP3 VHZ
Gene Names Primary:
DUSP23
Organism:
Homo sapiens (Human)

Structure

Length:
150
Sequence:
MGVQPPNFSWVLPGRLAGLALPRLPAHYQFLLDLGVRHLVSLTERGPPHSDSCPGLTLHRLRIPDFCPPAPDQIDRFVQIVDEANARGEAVGVHCALGFGRTGTMLACYLVKERGLAAGDAIAEIRRLRPGSIETYEQEKAVFQFYQRTK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear.

Function

Function:
Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).
Catalytic Activity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.498 mM for p-nitrophenylphosphate
Active Site:
ACT_SITE 95 95 Phosphocysteine intermediate.
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
nucleus
protein serine/threonine phosphatase activity
protein tyrosine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
peptidyl-tyrosine dephosphorylation
Gene Ontology Biological Process:
peptidyl-tyrosine dephosphorylation
Gene Ontology Molecular Function:
protein serine/threonine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
protein tyrosine phosphatase activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
nucleus
Keywords:
3D-structure
Complete proteome
Cytoplasm
Hydrolase
Nucleus
Polymorphism
Protein phosphatase
Reference proteome
Interacts With:
Q96B26; Q9GZT8

Publication

PubMed ID:
15281913 14702039 16710414 15489334 15201283 15147733 21269460 25944712 18245086