Names & Taxonomy

Uniprot ID:
Q9BVA1
Entry Name:
TBB2B_HUMAN
Status:
reviewed
Protein Names:
Tubulin beta-2B chain
Gene Names:
TUBB2B
Gene Names Primary:
TUBB2B
Organism:
Homo sapiens (Human)

Structure

Length:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytoskeleton

Function

Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB2B is implicated in neuronal migration.
Gene Ontology Go:
cytoplasm
microtubule
nucleus
GTP binding
GTPase activity
structural constituent of cytoskeleton
'de novo' posttranslational protein folding
cellular protein metabolic process
microtubule-based process
neuron migration
protein folding
Gene Ontology Biological Process:
'de novo' posttranslational protein folding
cellular protein metabolic process
microtubule-based process
neuron migration
protein folding
Gene Ontology Molecular Function:
GTPase activity
GTP binding
structural constituent of cytoskeleton
Gene Ontology Cellular Component:
cytoplasm
microtubule
nucleus
Keywords:
Acetylation
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
GTP-binding
Isopeptide bond
Methylation
Microtubule
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Interacts With:
O00555

Publication

PubMed ID:
14702039 14574404 15489334 19524510 19465910 20191564 21269460 26875866