Names & Taxonomy
- Uniprot ID:
- Q9BVA1
- Entry Name:
- TBB2B_HUMAN
- Status:
- reviewed
- Protein Names:
- Tubulin beta-2B chain
- Gene Names:
- TUBB2B
- Gene Names Primary:
- TUBB2B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 445
- Sequence:
- MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton
Function
- Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB2B is implicated in neuronal migration.
- Gene Ontology Go:
- cytoplasm
microtubule
nucleus
GTP binding
GTPase activity
structural constituent of cytoskeleton
'de novo' posttranslational protein folding
cellular protein metabolic process
microtubule-based process
neuron migration
protein folding - Gene Ontology Biological Process:
- 'de novo' posttranslational protein folding
cellular protein metabolic process
microtubule-based process
neuron migration
protein folding - Gene Ontology Molecular Function:
- GTPase activity
GTP binding
structural constituent of cytoskeleton - Gene Ontology Cellular Component:
- cytoplasm
microtubule
nucleus - Keywords:
- Acetylation
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
GTP-binding
Isopeptide bond
Methylation
Microtubule
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- O00555