Names & Taxonomy

Uniprot ID:
Q9BV57
Entry Name:
MTND_HUMAN
Status:
reviewed
Protein Names:
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54) (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD) (Fe-ARD) (Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1) (MTCBP-1) (Submergence-induced protein-like factor) (Sip-L)
Gene Names:
ADI1 MTCBP1 HMFT1638
Gene Names Orf:
HMFT1638
Gene Names Primary:
ADI1
Organism:
Homo sapiens (Human)

Structure

Length:
179
Sequence:
MVQAWYMDDAPGDPRQPHRPDPGRPVGLEQLRRLGVLYWKLDADKYENDPELEKIRRERNYSWMDIITICKDKLPNYEEKIKMFYEEHLHLDDEIRYILDGSGYFDVRDKEDQWIRIFMEKGDMVTLPAGIYHRFTVDEKNYTKAMRLFVGEPVWTAYNRPADHFEARGQYVKFLAQTA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.

Function

Function:
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.
Pathway:
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.
Catalytic Activity:
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-(methylthio)-2-oxobutanoate + formate.
Cofactor:
COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875;
Cross Reference Drug Bank:
DB02325
Gene Ontology Go:
cytoplasm
cytosol
nucleus
plasma membrane
acireductone dioxygenase activity
metal ion binding
oxidoreductase activity
cellular nitrogen compound metabolic process
L-methionine biosynthetic process from methylthioadenosine
polyamine metabolic process
small molecule metabolic process
sulfur amino acid metabolic process
Gene Ontology Biological Process:
cellular nitrogen compound metabolic process
L-methionine biosynthetic process from methylthioadenosine
polyamine metabolic process
small molecule metabolic process
sulfur amino acid metabolic process
Gene Ontology Molecular Function:
acireductone dioxygenase activity
metal ion binding
oxidoreductase activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
nucleus
plasma membrane
Keywords:
3D-structure
Alternative splicing
Amino-acid biosynthesis
Cell membrane
Complete proteome
Cytoplasm
Dioxygenase
Direct protein sequencing
Iron
Membrane
Metal-binding
Methionine biosynthesis
Nucleus
Oxidoreductase
Reference proteome
Interacts With:
P50281

Publication

PubMed ID:
14718544 15221005 14702039 15815621 15489334 19892738 11602742 15938715 21269460 24275569