Names & Taxonomy
- Uniprot ID:
- Q9BTZ2
- Entry Name:
- DHRS4_HUMAN
- Status:
- reviewed
- Protein Names:
- Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (NADPH-dependent retinol dehydrogenase/reductase) (NRDR) (humNRDR) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) (SCAD-SRL) (Short chain dehydrogenase/reductase family 25C member 2) (Short-chain dehydrogenase/reductase family member 4)
- Gene Names:
- DHRS4 SDR25C2 UNQ851/PRO1800
- Gene Names Orf:
- UNQ851/PRO1800
- Gene Names Primary:
- DHRS4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 278
- Sequence:
- MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Peroxisome
Function
- Function:
- Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).
- Catalytic Activity:
- R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
- Active Site:
- ACT_SITE 182 182 Proton acceptor.
- Cross Reference Drug Bank:
- DB00162
- Gene Ontology Go:
- endoplasmic reticulum membrane
extracellular exosome
intracellular membrane-bounded organelle
mitochondrion
nuclear membrane
nucleus
peroxisomal membrane
peroxisome
3-keto sterol reductase activity
alcohol dehydrogenase activity
carbonyl reductase (NADPH) activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
receptor binding
alcohol metabolic process
cellular ketone metabolic process
oxidation-reduction process
protein tetramerization
steroid metabolic process - Gene Ontology Biological Process:
- alcohol metabolic process
cellular ketone metabolic process
oxidation-reduction process
protein tetramerization
steroid metabolic process - Gene Ontology Molecular Function:
- 3-keto sterol reductase activity
alcohol dehydrogenase activity
carbonyl reductase (NADPH) activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
receptor binding - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
extracellular exosome
intracellular membrane-bounded organelle
mitochondrion
nuclear membrane
nucleus
peroxisomal membrane
peroxisome - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
NADP
Nucleus
Oxidoreductase
Peroxisome
Phosphoprotein
Polymorphism
Reference proteome