Names & Taxonomy
- Uniprot ID:
- Q99735
- Entry Name:
- MGST2_HUMAN
- Status:
- reviewed
- Protein Names:
- Microsomal glutathione S-transferase 2 (Microsomal GST-2) (EC 2.5.1.18) (Microsomal GST-II)
- Gene Names:
- MGST2 GST2
- Gene Names Primary:
- MGST2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 147
- Sequence:
- MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTLLGALGIANSFLDEYLDLNIAKKLRRQF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.
- Catalytic Activity:
- RX + glutathione = HX + R-S-glutathione.
- Cross Reference Drug Bank:
- DB01008 DB00143
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
plasma membrane
enzyme activator activity
glutathione peroxidase activity
glutathione transferase activity
leukotriene-C4 synthase activity
cellular oxidant detoxification
glutathione biosynthetic process
glutathione derivative biosynthetic process
leukotriene biosynthetic process
response to lipopolysaccharide
response to organonitrogen compound
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular oxidant detoxification
glutathione biosynthetic process
glutathione derivative biosynthetic process
leukotriene biosynthetic process
response to lipopolysaccharide
response to organonitrogen compound
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- enzyme activator activity
glutathione peroxidase activity
glutathione transferase activity
leukotriene-C4 synthase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
plasma membrane - Keywords:
- Alternative splicing
Complete proteome
Endoplasmic reticulum
Leukotriene biosynthesis
Membrane
Microsome
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix