Names & Taxonomy
- Uniprot ID:
- Q99707
- Entry Name:
- METH_HUMAN
- Status:
- reviewed
- Protein Names:
- Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Vitamin-B12 dependent methionine synthase) (MS)
- Gene Names:
- MTR
- Gene Names Primary:
- MTR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1265
- Sequence:
- MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKVIQTDEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGYDTD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
- Pathway:
- Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.
- Catalytic Activity:
- 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine.
- Cofactor:
- COFACTOR: Name=methyl(III)cobalamin; Xref=ChEBI:CHEBI:28115; ; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Cross Reference Drug Bank:
- DB00115 DB00200 DB00134 DB00116
- Gene Ontology Go:
- cytoplasm
cytosol
cobalamin binding
methionine synthase activity
S-adenosylmethionine-homocysteine S-methyltransferase activity
zinc ion binding
axon regeneration
cellular nitrogen compound metabolic process
cellular response to nitric oxide
cobalamin metabolic process
methionine biosynthetic process
methylation
nervous system development
pteridine-containing compound metabolic process
response to axon injury
small molecule metabolic process
sulfur amino acid metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- axon regeneration
cellular nitrogen compound metabolic process
cellular response to nitric oxide
cobalamin metabolic process
methionine biosynthetic process
methylation
nervous system development
pteridine-containing compound metabolic process
response to axon injury
small molecule metabolic process
sulfur amino acid metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- cobalamin binding
methionine synthase activity
S-adenosylmethionine-homocysteine S-methyltransferase activity
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol - Keywords:
- 3D-structure
Alternative splicing
Amino-acid biosynthesis
Cobalamin
Cobalt
Complete proteome
Cytoplasm
Disease mutation
Metal-binding
Methionine biosynthesis
Methyltransferase
Phosphoprotein
Polymorphism
Reference proteome
Repeat
S-adenosyl-L-methionine
Transferase
Zinc - Interacts With:
- Q9Y4U1